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Gene Review

Tgfb3  -  transforming growth factor, beta 3

Rattus norvegicus

Synonyms: TGF-beta-3, Tgf-b3, Transforming growth factor beta-3
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Disease relevance of Tgfb3


Psychiatry related information on Tgfb3


High impact information on Tgfb3

  • Furthermore, we find that TGF beta 2, TGF beta 3, and GDNF are expressed sequentially as local and target-derived trophic factors and that subpopulations of dopaminergic neurons projecting to distinct targets have access to only one of these factors [2].
  • We report here that transforming growth factors (TGFs) TGF beta 2 and TGF beta 3, which are distantly related to GDNF, also prevent the death of cultured rat embryonic midbrain dopaminergic neurons at picomolar concentrations [2].
  • We investigated the effects of intracerebral administration of GDNF and TGF-beta 3 on the delayed cell death of the dopamine neurons in the rat substantia nigra following 6-hydroxydopamine lesions of dopaminergic terminals in the striatum [6].
  • Scatchard analysis of receptor competition studies indicated the presence of high-affinity binding sites for TGF-beta 3 in the picomolar range [7].
  • In this report we demonstrate that TGF-beta 3 is a potent regulator of functions associated with bone formation, i.e., mitogenesis, collagen synthesis, and alkaline phosphatase activity [7].

Biological context of Tgfb3


Anatomical context of Tgfb3


Associations of Tgfb3 with chemical compounds


Regulatory relationships of Tgfb3


Other interactions of Tgfb3

  • This result clearly illustrates that CdCl(2) mediates its BTB disruptive effects via the TGF-beta3/p38 MAP kinase signaling pathway [12].
  • TGF-beta 3 staining was increased at day 10 only, and TGF-beta 1 was unchanged [22].
  • We found that TGF-beta3 and estradiol alone moderately increased cell content and release of bFGF from FS cells; but together, they markedly increased the peptide [16].
  • Astroglial cells from all brain regions showed a slight FGF-mediated increase in 5-bromo-2'-desoxy-uridine (BrdU) incorporation, which was abolished upon co-treatment with TGF-beta3 [23].
  • In bladders subjected to partial urethral outlet obstruction, there was a 2-fold increase in mRNA for TGF beta 2, a 5-fold increase in TGF beta 3, and a 10-fold increase TGF alpha mRNA [24].

Analytical, diagnostic and therapeutic context of Tgfb3


  1. Selective expression of TGF-beta2 and TGF-beta3 isoforms in early mesangioproliferative glomerulonephritis. Minto, A.W., Wilson, H.M., Rees, A.J., Quigg, R.J., Brown, P.A. Nephron Exp. Nephrol. (2004) [Pubmed]
  2. TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Poulsen, K.T., Armanini, M.P., Klein, R.D., Hynes, M.A., Phillips, H.S., Rosenthal, A. Neuron (1994) [Pubmed]
  3. Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. Wang, J., Zheng, H., Sung, C.C., Richter, K.K., Hauer-Jensen, M. Am. J. Pathol. (1998) [Pubmed]
  4. Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis. Wilson, H.M., Minto, A.W., Brown, P.A., Erwig, L.P., Rees, A.J. Kidney Int. (2000) [Pubmed]
  5. Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats. Yamazaki, H., Arai, M., Matsumura, S., Inoue, K., Fushiki, T. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  6. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Sauer, H., Rosenblad, C., Björklund, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells. ten Dijke, P., Iwata, K.K., Goddard, C., Pieler, C., Canalis, E., McCarthy, T.L., Centrella, M. Mol. Cell. Biol. (1990) [Pubmed]
  8. Radiation-induced alterations in rat mesangial cell Tgfb1 and Tgfb3 gene expression are not associated with altered secretion of active Tgfb isoforms. O'Malley, Y., Zhao, W., Barcellos-Hoff, M.H., Robbins, M.E. Radiat. Res. (1999) [Pubmed]
  9. Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organization. Soo, C., Beanes, S.R., Hu, F.Y., Zhang, X., Dang, C., Chang, G., Wang, Y., Nishimura, I., Freymiller, E., Longaker, M.T., Lorenz, H.P., Ting, K. Am. J. Pathol. (2003) [Pubmed]
  10. Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. Wang, J., Kuliszewski, M., Yee, W., Sedlackova, L., Xu, J., Tseu, I., Post, M. J. Biol. Chem. (1995) [Pubmed]
  11. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia, W., Mruk, D.D., Lee, W.M., Cheng, C.Y. J. Biol. Chem. (2006) [Pubmed]
  12. Regulation of blood-testis barrier dynamics: an in vivo study. Wong, C.H., Mruk, D.D., Lui, W.Y., Cheng, C.Y. J. Cell. Sci. (2004) [Pubmed]
  13. Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Lui, W.Y., Lee, W.M., Cheng, C.Y. Endocrinology (2001) [Pubmed]
  14. TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Lui, W.Y., Wong, C.H., Mruk, D.D., Cheng, C.Y. Endocrinology (2003) [Pubmed]
  15. Dynamic expression of transforming growth factor-betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats. Müssener, A., Funa, K., Kleinau, S., Klareskog, L. Clin. Exp. Immunol. (1997) [Pubmed]
  16. Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells. Chaturvedi, K., Sarkar, D.K. Endocrinology (2004) [Pubmed]
  17. Role of protein kinase C-Ras-MAPK p44/42 in ethanol and transforming growth factor-beta3-induced basic fibroblast growth factor release from folliculostellate cells. Chaturvedi, K., Sarkar, D.K. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  18. Complex regulation of TGF beta expression by retinoic acid in the vitamin A-deficient rat. Glick, A.B., McCune, B.K., Abdulkarem, N., Flanders, K.C., Lumadue, J.A., Smith, J.M., Sporn, M.B. Development (1991) [Pubmed]
  19. Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR. Wickert, L., Steinkrüger, S., Abiaka, M., Bolkenius, U., Purps, O., Schnabel, C., Gressner, A.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  20. Glucocorticoid-induced tropoelastin expression is mediated via transforming growth factor-beta 3. Yee, W., Wang, J., Liu, J., Tseu, I., Kuliszewski, M., Post, M. Am. J. Physiol. (1996) [Pubmed]
  21. TGF-beta 3 inhibits the increased gene expressions of pulmonary surfactant proteins induced by dexamethasone in fetal rat lung in vitro. Wang, X., Jin, Q., Xu, J., Shen, W., Wang, J., Post, M. Chin. Med. J. (1997) [Pubmed]
  22. Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy. Shankland, S.J., Pippin, J., Pichler, R.H., Gordon, K.L., Friedman, S., Gold, L.I., Johnson, R.J., Couser, W.G. Kidney Int. (1996) [Pubmed]
  23. Fibroblast growth factor 2 (FGF-2) differentially regulates connexin (cx) 43 expression and function in astroglial cells from distinct brain regions. Reuss, B., Dermietzel, R., Unsicker, K. Glia (1998) [Pubmed]
  24. Growth factors and receptors in bladder development and obstruction. Baskin, L.S., Sutherland, R.S., Thomson, A.A., Hayward, S.W., Cunha, G.R. Lab. Invest. (1996) [Pubmed]
  25. Early alteration in TGF-beta mRNA expression in irradiated rat liver. Seong, J., Kim, S.H., Chung, E.J., Lee, W.J., Suh, C.O. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  26. The effect of surgical trauma on rat tunica albuginea. El-Sakka, A.I., Selph, C.A., Yen, T.S., Dahiya, R., Lue, T.F. J. Urol. (1998) [Pubmed]
  27. Cellular localisation of transforming growth factor-beta 2 and -beta 3 (TGF-beta2, TGF-beta3) in damaged and regenerating skeletal muscles. McLennan, I.S., Koishi, K. Dev. Dyn. (1997) [Pubmed]
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