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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling.

The importance of reversible phosphorylation for neuronal signaling and cell survival is well recognized. Knowledge in vertebrates, however, is so far limited to O-phosphates from serine, threonine, and tyrosine. The authors describe an enzyme acting on N-phosphates. It is the first protein histidine phosphatase identified in vertebrates. This histidine phosphatase is ubiquitously expressed in mammalian tissues including brain. Characterization and sequencing showed a yet unknown protein with no similarity to other phosphatases. In Caenorhabditis elegans, the homolog of this histidine phosphatase was exclusively expressed in neurons, suggesting a distinct role of reversible histidine phosphorylation in neuronal functions.[1]

References

  1. Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling. Klumpp, S., Hermesmeier, J., Selke, D., Baumeister, R., Kellner, R., Krieglstein, J. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
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