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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Chondromodulin I is a bone remodeling factor.

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor.[1]

References

  1. Chondromodulin I is a bone remodeling factor. Nakamichi, Y., Shukunami, C., Yamada, T., Aihara, K., Kawano, H., Sato, T., Nishizaki, Y., Yamamoto, Y., Shindo, M., Yoshimura, K., Nakamura, T., Takahashi, N., Kawaguchi, H., Hiraki, Y., Kato, S. Mol. Cell. Biol. (2003) [Pubmed]
 
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