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Gene Review

Lect1  -  leukocyte cell derived chemotaxin 1

Mus musculus

Synonyms: Bricd3, ChM-I, Chmi, Chondromodulin 1, Leukocyte cell-derived chemotaxin 1
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Disease relevance of Lect1


High impact information on Lect1


Biological context of Lect1


Anatomical context of Lect1


Associations of Lect1 with chemical compounds


Analytical, diagnostic and therapeutic context of Lect1

  • CONCLUSIONS: These results indicate a potential role for TeM in prevention of vascular invasion in the mouse eye and the possibility of both TeM and ChM-I as candidates for use in gene therapy approaches to treatment of ocular angiogenesis [4].
  • METHODS: The localization of ChM-I expression in mouse thymus tissue was examined by in situ hybridization [8].
  • Northern blot analysis revealed that the chondromodulin-I transcripts were expressed in association with the formation of cartilage expressing type II collagen from days 11 to 17 of gestation in mouse embryos, at which time cartilaginous bone rudiments were gradually replaced by bone [6].


  1. Chondromodulin I is a bone remodeling factor. Nakamichi, Y., Shukunami, C., Yamada, T., Aihara, K., Kawano, H., Sato, T., Nishizaki, Y., Yamamoto, Y., Shindo, M., Yoshimura, K., Nakamura, T., Takahashi, N., Kawaguchi, H., Hiraki, Y., Kato, S. Mol. Cell. Biol. (2003) [Pubmed]
  2. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Docheva, D., Hunziker, E.B., Fässler, R., Brandau, O. Mol. Cell. Biol. (2005) [Pubmed]
  3. Myodulin is a novel potential angiogenic factor in skeletal muscle. Pisani, D.F., Pierson, P.M., Massoudi, A., Leclerc, L., Chopard, A., Marini, J.F., Dechesne, C.A. Exp. Cell Res. (2004) [Pubmed]
  4. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Oshima, Y., Shukunami, C., Honda, J., Nishida, K., Tashiro, F., Miyazaki, J., Hiraki, Y., Tano, Y. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  5. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene. Shukunami, C., Oshima, Y., Hiraki, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation. Shukunami, C., Iyama, K., Inoue, H., Hiraki, Y. Int. J. Dev. Biol. (1999) [Pubmed]
  7. Chondromodulin I is dispensable during enchondral ossification and eye development. Brandau, O., Aszódi, A., Hunziker, E.B., Neame, P.J., Vestweber, D., Fässler, R. Mol. Cell. Biol. (2002) [Pubmed]
  8. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis. Setoguchi, K., Misaki, Y., Kawahata, K., Shimada, K., Juji, T., Tanaka, S., Oda, H., Shukunami, C., Nishizaki, Y., Hiraki, Y., Yamamoto, K. Arthritis Rheum. (2004) [Pubmed]
  9. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues. Shukunami, C., Oshima, Y., Hiraki, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I. Yamana, K., Wada, H., Takahashi, Y., Sato, H., Kasahara, Y., Kiyoki, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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