- Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Puolakkainen, P., Bradshaw, A.D., Kyriakides, T.R., Reed, M., Brekken, R., Wight, T., Bornstein, P., Ratner, B., Sage, E.H. Am. J. Pathol. (2003)