Disease relevance of Foreign Bodies

• No suppression of these footpad reactions was observed in mice bearing small latex foreign-body granulomas [1].
• Fc-receptor-bearing macrophages isolated from hypersensitivity and foreign-body granulomas. Delineation of macrophage dynamics, fc receptor density/avidity and specificity [2].
• Staphylococcus aureus has a special predilection to cause infections involving prosthetic devices, perhaps related to its affinity for fibronectin, laminin, and other serum proteins that can mediate attachment to foreign material; 46 of 162 (28%) infections were associated with the presence of a foreign body [3].
• The local effect of an implanted foreign body (polyvinyl chloride film) on the growth of transplanted syngeneic sarcoma cells was studied [4].
• These results suggest that pleiotropic effects of the Bcg gene are involved in the development of granulomas induced by either BCG or nonspecific foreign body agents (dextran beads) and that monokines participate in granuloma formation [5].

Psychiatry related information on Foreign Bodies

• The results are discussed on the basis of inflammatory reaction elicited from the foreign body and the characteristics of clindamycin in connection with the host's defense mechanisms [6].

High impact information on Foreign Bodies

• Synthetic vascular prostheses are foreign bodies, so that blood coagulation can occur on their luminal surfaces, causing graft occlusion very frequently in prostheses of small diameter [7].
• The types of packages can often be distinguished roentgenographically; however, 12 patients who passed cocaine packages had abdominal roentgenograms that did not show these foreign bodies [8].
• 'Radiopaque' foreign bodies [9].
• DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells [10].
• Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction [11].

Chemical compound and disease context of Foreign Bodies

• Foreign-body reactions were induced in coisogenic CBA/H and CBA/H-T6 mice by sc implantation of 15 times 22 times 0.2-mm unplasticized vinyl chloride vinyl acetate copolymer films [12].
• We investigated whether vinyl chloride monomers, released from implants of vinyl chloride vinyl acetate copolymer (VCA), exerted cocarcinogenic activity and added thereby to the mechanism of foreign-body (FB) tumorigenesis [13].
• The results suggest that estrogen influences the pace of foreign-body tumorigenesis in CBA/H mice [14].
• Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice [15].
• Delayed foreign-body tumorigenesis in mice infected with lactate dehydrogenase-elevating virus: Brief communication [16].

Biological context of Foreign Bodies

• Consideration of this phenotype suggested to us that the foreign body reaction (FBR) might be altered in thrombospondin 2 (TSP2)-null mice [17].
• The matricellular angiogenesis inhibitor, thrombospondin (TSP) 2, has been shown to be an important modulator of wound healing and the foreign body response [18].
• Augmentation of pulmonary foreign body granulomatous inflammation in mice by lipopolysaccharide: involvement of macrophage activation and tumor necrosis factor-alpha [19].
• To probe the role of human plasma fibronectin in modulating human blood-derived macrophage adhesion and fusion to form multinucleated foreign-body giant cells (FBGC), a series of biomimetic oligopeptides based on the functional structure of fibronectin was designed and synthesized [20].
• Among the possible causes of these deleterious episodes were microcrystalluria, obstipation, a decubitus ulcer, a foreign body in the buttocks, drug tolerance to baclofen, electromagnetic interference, and erroneous filling and programing of the pump [21].

Anatomical context of Foreign Bodies

• Nitric oxide synthase is expressed in human macrophages during foreign body inflammation [22].
• In addition to its well-known effects on the uterus, progesterone may be important in suppressing the inflammatory reaction that would be expected in response to the presence of a foreign body, such as an embryo [23].
• The lesion was composed of numerous small granulomas (Ziehl-Nielsen negative), with no foreign bodies, mainly composed of CD68-positive and periodic acid Schiff-negative monocytes [24].
• In 1 patient, the seed migration detector sensed radioactivity in the thorax, but repeat chest radiographic examinations failed to show a radiopaque foreign body in the chest cavity [25].
• Prolongedextraction with 8 m urea yeilded increases amounts of radioactivie protein form older (8-to 26-week) allergic granulomas but not from 4-to6-week-old or foreign body granulomas (consisting of mononuclear cells and phagocytes) [26].

Gene context of Foreign Bodies

• Specifically, TSP2-null mice display improved healing with minimal scarring and form well-vascularized foreign body capsules [18].
• Foreign body lesions showed minimal IL-1 expression [27].
• This suggests that lack of proteolytic enzymes or TNF-alpha or IFN-gamma is not the cause of the impaired onset of the foreign-body reaction [28].
• Further analysis revealed that the hydrophilic and anionic surfaces inhibited monocyte adhesion and IL-4-mediated macrophage fusion into foreign body giant cells (FBGCs) [29].
• DESIGN: Immunoreactivity for CD117 (c-Kit), MITF, TRAP, and HAM-56 was studied in 35 GCTBs, 15 GCTTSs, and 5 foreign-body GC controls [30].

Analytical, diagnostic and therapeutic context of Foreign Bodies

• A novel model of experimental foreign body infection was developed in rats: four perforated Teflon tissue cages per animal were implanted subcutaneously and 3 to 4 weeks later were infected with 0.5 x 10(5) to 2 x 10(5) CFU of methicillin-resistant Staphylococcus aureus [31].
• OBJECTIVE: This study aimed to compare the effectiveness of helical computed tomography (CT) versus conventional CT in the preoperative assessment of metallic intraocular foreign bodies on axial, coronal, and multiplanar reconstruction images in clinical routine [32].
• Other risk factors included urinary tract infection, foreign bodies, vesicoureteral reflux and urinary stasis but not acidosis or immobilization [33].
• In 1,174 cases EBUS was used (29% mechanical tumour debridement, 20% airway stenting, 13% Neodymium:yttrium aluminium garnet (Nd:YAG) laser use, 23% argon plasma coagulation, 11% brachytherapy, 2% foreign body removal and 2% endoscopic abscess drainage) [34].
• The metallic foreign body was removed during a pars plana lensectomy and anterior vitrectomy procedure; intravitreously injected methicillin sodium, gentamicin sulfate, and dexamethasone sodium phosphate gave a functional visual result [35].

References