Gene Review:
Sparc - secreted acidic cysteine rich glycoprotein
Mus musculus
Synonyms:
AA517111, BM-40, Basement-membrane protein 40, ON, Osteonectin, ...
Schiemann,
Julie A. Wilkins,
Schilling,
Owen J. Sansom,
Ullrich,
Menger,
Shankland,
Inoue,
Chavey,
Alan R. Clarke,
Fiona C. Mansergh,
Bornstein,
Sage,
Monthouel,
Puolakkainen,
Tartare-Deckert,
Ikemoto,
Vajkoczy,
Van Obberghen,
Fong,
Bradshaw,
Funk,
Schiemann,
Hirth,
Durvasula,
Rempel,
Takita,
Martin J. Evans,
Neil,
Vernon,
Reed,
Wight,
Brekken,
Tonn,
Gautier,
Vollmar,
Kyriakides,
Goldbrunner,
Gooden,
Ge,
Imamura,
Schmiedek,
- SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. Barker, T.H., Baneyx, G., Cardó-Vila, M., Workman, G.A., Weaver, M., Menon, P.M., Dedhar, S., Rempel, S.A., Arap, W., Pasqualini, R., Vogel, V., Sage, E.H. J. Biol. Chem. (2005)
- Reduced excision repair cross-complementing 1 expression associates with enhanced papilloma formation and fibroblast transformation after genetic disruption of secreted protein acidic and rich in cysteine. Kato, Y., Tsukuda, M., Nagashima, Y., Koshika, S., Sakai, N., Yao, M., Kubota, Y., Aoki, I., Colledge, W.H., Foidart, J.M., Hata, R., Thompson, E.W. Int. J. Oncol. (2005)
- Osteopenia and decreased bone formation in osteonectin-deficient mice. Delany, A.M., Amling, M., Priemel, M., Howe, C., Baron, R., Canalis, E. J. Clin. Invest. (2000)
- Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Puolakkainen, P., Bradshaw, A.D., Kyriakides, T.R., Reed, M., Brekken, R., Wight, T., Bornstein, P., Ratner, B., Sage, E.H. Am. J. Pathol. (2003)
- Mechanical strain increases SPARC levels in podocytes: implications for glomerulosclerosis. Durvasula, R.V., Shankland, S.J. Am. J. Physiol. Renal Physiol. (2005)
- Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Sansom, O.J., Mansergh, F.C., Evans, M.J., Wilkins, J.A., Clarke, A.R. Gut (2007)
- Increased sensitivity to the stimulant effects of morphine conferred by anti-adhesive glycoprotein SPARC in amygdala. Ikemoto, M., Takita, M., Imamura, T., Inoue, K. Nat. Med. (2000)
- The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. Tartare-Deckert, S., Chavey, C., Monthouel, M.N., Gautier, N., Van Obberghen, E. J. Biol. Chem. (2001)
- Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. Sangaletti, S., Stoppacciaro, A., Guiducci, C., Torrisi, M.R., Colombo, M.P. J. Exp. Med. (2003)
- Bleomycin-induced pulmonary injury in mice deficient in SPARC. Savani, R.C., Zhou, Z., Arguiri, E., Wang, S., Vu, D., Howe, C.C., DeLisser, H.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2000)
- Purification and tissue distribution of a small protein (BM-40) extracted from a basement membrane tumor. Dziadek, M., Paulsson, M., Aumailley, M., Timpl, R. Eur. J. Biochem. (1986)
- Amelioration of diabetic nephropathy in SPARC-null mice. Taneda, S., Pippin, J.W., Sage, E.H., Hudkins, K.L., Takeuchi, Y., Couser, W.G., Alpers, C.E. J. Am. Soc. Nephrol. (2003)
- Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. Vajkoczy, P., Menger, M.D., Goldbrunner, R., Ge, S., Fong, T.A., Vollmar, B., Schilling, L., Ullrich, A., Hirth, K.P., Tonn, J.C., Schmiedek, P., Rempel, S.A. Int. J. Cancer (2000)
- Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. Mason, I.J., Murphy, D., Münke, M., Francke, U., Elliott, R.W., Hogan, B.L. EMBO J. (1986)
- The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene. McKinnon, P.J., Kapsetaki, M., Margolskee, R.F. Genome Res. (1996)
- Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens. Mansergh, F.C., Wride, M.A., Walker, V.E., Adams, S., Hunter, S.M., Evans, M.J. Mol. Vis. (2004)
- Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. Gilmour, D.T., Lyon, G.J., Carlton, M.B., Sanes, J.R., Cunningham, J.M., Anderson, J.R., Hogan, B.L., Evans, M.J., Colledge, W.H. EMBO J. (1998)
- Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation. Bassuk, J.A., Birkebak, T., Rothmier, J.D., Clark, J.M., Bradshaw, A., Muchowski, P.J., Howe, C.C., Clark, J.I., Sage, E.H. Exp. Eye Res. (1999)
- Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. Nomura, S., Wills, A.J., Edwards, D.R., Heath, J.K., Hogan, B.L. J. Cell Biol. (1988)
- Expression of matrix proteins during the development of mineralized tissues. Sommer, B., Bickel, M., Hofstetter, W., Wetterwald, A. Bone (1996)
- Expression of genes encoding connective tissue proteins in androgen-dependent SC115 tumors after androgen removal. Nagoshi, J., Nomura, S., Uchida, N., Hirota, S., Ito, A., Nakase, T., Hirakawa, K., Shiozaki, H., Mori, T., Kitamura, Y. Lab. Invest. (1994)
- SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. Puolakkainen, P.A., Bradshaw, A.D., Brekken, R.A., Reed, M.J., Kyriakides, T., Funk, S.E., Gooden, M.D., Vernon, R.B., Wight, T.N., Bornstein, P., Sage, E.H. J. Histochem. Cytochem. (2005)
- SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. Nie, J., Sage, E.H. J. Biol. Chem. (2009)
- Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Nakase, T., Takaoka, K., Hirakawa, K., Hirota, S., Takemura, T., Onoue, H., Takebayashi, K., Kitamura, Y., Nomura, S. Bone and mineral. (1994)
- Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. Delany, A.M., Canalis, E. Am. J. Physiol. (1998)
- Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Iruela-Arispe, M.L., Vernon, R.B., Wu, H., Jaenisch, R., Sage, E.H. Dev. Dyn. (1996)
- Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis. Barker, T.H., Framson, P., Puolakkainen, P.A., Reed, M., Funk, S.E., Sage, E.H. Am. J. Pathol. (2005)
- Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro. Stary, M., Pasteiner, W., Summer, A., Hrdina, A., Eger, A., Weitzer, G. Exp. Cell Res. (2005)
- Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4. Hirota, S., Takaoka, K., Hashimoto, J., Nakase, T., Takemura, T., Morii, E., Fukuyama, A., Morihana, K., Kitamura, Y., Nomura, S. Cell Tissue Res. (1994)
- Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC. Aycock, R.L., Bradshaw, A.C., Sage, E.H., Starcher, B. J. Invest. Dermatol. (2004)
- The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. Weaver, M.S., Workman, G., Sage, E.H. J. Biol. Chem. (2008)
- Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). Barlow, D.P., Bućan, M., Lehrach, H., Hogan, B.L., Gough, N.M. EMBO J. (1987)
- Expression of genes for non-collagenous proteins during embryonic bone formation. Nomura, S., Wills, A.J., Edwards, D.R., Heath, J.K., Hogan, B.L. Connect. Tissue Res. (1989)
- SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system. Schiemann, B.J., Neil, J.R., Schiemann, W.P. Mol. Biol. Cell (2003)
- In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. Holland, P.W., Harper, S.J., McVey, J.H., Hogan, B.L. J. Cell Biol. (1987)
- Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. Mason, I.J., Taylor, A., Williams, J.G., Sage, H., Hogan, B.L. EMBO J. (1986)