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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice.

We investigated whether fenofibrate improves lipid metabolism and obesity in female ovariectomized (OVX) or sham-operated (SO) low density lipoprotein receptor-null (LDLR-null) mice. All mice fed a high-fat diet exhibited increases in serum triglycerides and cholesterol as well as in body weight and white adipose tissue (WAT) mass compared to mice fed a low fat control diet. However, fenofibrate prevented high-fat diet-induced increases in body weight and WAT mass in female OVX LDLR-null mice, but not in SO mice. In addition, administration of fenofibrate reduced serum lipids and hepatic apolipoprotein C-III mRNA while increasing the mRNA of acyl-CoA oxidase in both groups of mice, however, these effects were more pronounced in OVX LDLR-null mice. The results of this study provide first evidence that fenofibrate improves both lipid metabolism and obesity, in part through PPARalpha activation, in female OVX LDLR-null mice.[1]

References

  1. Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice. Yoon, M., Jeong, S., Lee, H., Han, M., Kang, J.H., Kim, E.Y., Kim, M., Oh, G.T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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