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Ohno, S. et al.

Ohno, Murakami, Tanimoto, Sugiyama, Makihira, Shibata, Yoneno, Kato, Tanne,

Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle.

BACKGROUND: The objective of this study was to investigate the expression of matrilin-1 in arthritic articular cartilage of the mandibular condyle by means of immunohistochemical methods. METHODS: Condylar cartilage specimens were obtained from temporomandibular joints (TMJs) of 12 patients with arthritis (osteoarthritis and internal derangement) (mean age 51.8 years; age range 28-71 years) and four patients with TMJ ankylosis (mean age 44.0 years; age range 16-64 years), diagnosed clinically and with imaging examinations. Paraffin sections were immunostained with anti-matrilin-1 antibodies. RESULTS: Matrilin-1 expression was detected in both patient groups with TMJ ankylosis and arthritis, and the level was remarkably higher in arthritic cartilage. The mean percentage of matrilin-1-producing cells to the total chondrocytes was significantly (P < 0.05) greater in the arthritic group (43.9 +/- 19.2%) than in subjects with TMJ ankylosis (28.0 +/- 8.7%). CONCLUSIONS: Articular chondrocytes in the TMJ condyle can express matrilin-1 and the expression is enhanced in arthritic cartilage, suggesting a presence of functional or adaptive remodeling in the condyle in response to degenerative changes in the TMJ structures.[1]

References

Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle. Ohno, S., Murakami, K., Tanimoto, K., Sugiyama, H., Makihira, S., Shibata, T., Yoneno, K., Kato, Y., Tanne, K. J. Oral Pathol. Med. (2003) [Pubmed]

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