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MeSH Review

Temporomandibular Joint

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Disease relevance of Temporomandibular Joint


Psychiatry related information on Temporomandibular Joint


High impact information on Temporomandibular Joint

  • Temporomandibular joint dislocation mistaken as dystonia [9].
  • Jaw muscle responses similar to those evoked by MO application to the TMJ region were achieved with glutamate, NMDA, AMPA, and kainate [10].
  • It is possible that peripheral excitatory amino acid (EAA) receptors play a role in this effect, because MO-evoked increases in jaw muscle activity are attenuated by preapplication of the noncompetitive NMDA receptor antagonist MK-801 into the TMJ region [10].
  • This evidence suggests that both NMDA and non-NMDA EAA receptor types are located within the TMJ region and may contribute to jaw muscle activity that can be reflexively evoked from the TMJ region [10].
  • In the present study the EAA receptor agonists glutamate, NMDA, kainate, and AMPA were applied locally to the TMJ region [10].

Chemical compound and disease context of Temporomandibular Joint


Biological context of Temporomandibular Joint


Anatomical context of Temporomandibular Joint


Associations of Temporomandibular Joint with chemical compounds

  • RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production [25].
  • METHODS: Twenty-three children ages 4-16 years with JIA and MRI evidence of TMJ inflammation received CT-guided TMJ injections of corticosteroid (triamcinolone acetonide [n = 16] or triamcinolone hexacetonide [n = 7]) [26].
  • Temporomandibular joint noises were found in 9 patients, and occlusal changes (12 m mylar strip and wax bite, relative to pretreatment) in 15 [27].
  • Temporomandibular joint: value of coronal MR images [28].
  • The TMJ injection of formalin significantly increased the asymmetrical orofacial rubbing and head flinching behaviors, but not the movement of the mandible with concentrations of 1.5% and above (P<0.05, Dunn's test) when compared with the NaCl (0.9%) injection [29].

Gene context of Temporomandibular Joint


Analytical, diagnostic and therapeutic context of Temporomandibular Joint


  1. Tyramine conjugation deficit in patients with chronic idiopathic temporomandibular joint and orofacial pain. Aghabeigi, B., Feinmann, C., Glover, V., Goodwin, B., Hannah, P., Harris, M., Sandler, M., Wasil, M. Pain (1993) [Pubmed]
  2. Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. Ahn, D.K., Chae, J.M., Choi, H.S., Kyung, H.M., Kwon, O.W., Park, H.S., Youn, D.H., Bae, Y.C. Pain (2005) [Pubmed]
  3. Experimentally induced unilateral tooth loss: histochemical studies of the temporomandibular joint. Huang, Q., Opstelten, D., Samman, N., Tideman, H. J. Dent. Res. (2002) [Pubmed]
  4. Occlusal and TMJ loads in subjects with experimentally shortened dental arches. Hattori, Y., Satoh, C., Seki, S., Watanabe, Y., Ogino, Y., Watanabe, M. J. Dent. Res. (2003) [Pubmed]
  5. NF-kappaB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis. Yamaza, T., Masuda, K.F., Tsukiyama, Y., Nishijima, K., Murakami, R., Kido, M.A., Koyano, K., Tanaka, T. J. Dent. Res. (2003) [Pubmed]
  6. Sleep apnoea syndrome secondary to rheumatoid arthritis. Pépin, J.L., Della Negra, E., Grosclaude, S., Billon, C., Lévy, P. Thorax (1995) [Pubmed]
  7. TMJ pain in relation to circulating neuropeptide Y, serotonin, and interleukin-1 beta in rheumatoid arthritis. Alstergren, P., Ernberg, M., Kopp, S., Lundeberg, T., Theodorsson, E. Journal of orofacial pain. (1999) [Pubmed]
  8. Tiagabine may reduce bruxism and associated temporomandibular joint pain. Kast, R.E. Anesthesia progress. (2005) [Pubmed]
  9. Temporomandibular joint dislocation mistaken as dystonia. Vora, S.B., Feinsod, R., Annitto, W. JAMA (1979) [Pubmed]
  10. Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles. Cairns, B.E., Sessle, B.J., Hu, J.W. J. Neurosci. (1998) [Pubmed]
  11. Substance P-associated increase of intra-articular temperature and pain threshold in the arthritic TMJ. Appelgren, A., Appelgren, B., Kopp, S., Lundeberg, T., Theodorsson, E. Journal of orofacial pain. (1998) [Pubmed]
  12. Temporomandibular joint iontophoresis: a double-blind randomized clinical trial. Schiffman, E.L., Braun, B.L., Lindgren, B.R. Journal of orofacial pain. (1996) [Pubmed]
  13. Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints. Ishimaru, J.I., Ogi, N., Mizuno, S., Goss, A.N. Osteoarthr. Cartil. (2001) [Pubmed]
  14. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. Thie, N.M., Prasad, N.G., Major, P.W. J. Rheumatol. (2001) [Pubmed]
  15. A determination of tumor necrosis factor expression in TMJ inflammation with the use of microarray analysis. Spears, R., Oakes, R., Moore, C., Bellinger, L.L., Hutchins, B. J. Dent. Res. (2003) [Pubmed]
  16. Sex differences in brainstem neural activation after injury to the TMJ region. Bereiter, D.A. Cells Tissues Organs (Print) (2001) [Pubmed]
  17. Peripheral effect of a kappa opioid receptor antagonist on nociception evoked by formalin injected in TMJ of pregnant rats. Arthuri, M.T., Gameiro, G.H., Tambeli, C.H., de Arruda Veiga, M.C. Life Sci. (2005) [Pubmed]
  18. Evaluation of acupuncture and occlusal splint therapy in the treatment of temporomandibular joint disorders. Elsharkawy, T.M., Ali, N.M. Egyptian dental journal. (1995) [Pubmed]
  19. Occlusal harmony and disharmony: frauds in clinical dentistry? Møller, E., Bakke, M. International dental journal. (1988) [Pubmed]
  20. Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging. Gepstein, A., Shapiro, S., Arbel, G., Lahat, N., Livne, E. Arthritis Rheum. (2002) [Pubmed]
  21. Pain and synovial fluid concentration of serotonin in arthritic temporomandibular joints. Alstergren, P., Kopp, S. Pain (1997) [Pubmed]
  22. Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats. Shinoda, M., Ozaki, N., Asai, H., Nagamine, K., Sugiura, Y. Pain (2005) [Pubmed]
  23. The uptake of horseradish peroxidase in monkey temporomandibular joint synovium after occlusal alteration. Kubo, Y. J. Dent. Res. (1987) [Pubmed]
  24. Induction of MMP-3 by hyaluronan oligosaccharides in temporomandibular joint chondrocytes. Ohno, S., Ohno-Nakahara, M., Knudson, C.B., Knudson, W. J. Dent. Res. (2005) [Pubmed]
  25. Cyclic tensile strain suppresses catabolic effects of interleukin-1beta in fibrochondrocytes from the temporomandibular joint. Agarwal, S., Long, P., Gassner, R., Piesco, N.P., Buckley, M.J. Arthritis Rheum. (2001) [Pubmed]
  26. Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritis. Arabshahi, B., Dewitt, E.M., Cahill, A.M., Kaye, R.D., Baskin, K.M., Towbin, R.B., Cron, R.Q. Arthritis Rheum. (2005) [Pubmed]
  27. Dental side effects of an oral device to treat snoring and obstructive sleep apnea. Pantin, C.C., Hillman, D.R., Tennant, M. Sleep. (1999) [Pubmed]
  28. Temporomandibular joint: value of coronal MR images. Brooks, S.L., Westesson, P.L. Radiology. (1993) [Pubmed]
  29. Development of a behavioral model of TMJ pain in rats: the TMJ formalin test. Roveroni, R.C., Parada, C.A., Cecília, M., Veiga, F.A., Tambeli, C.H. Pain (2001) [Pubmed]
  30. Correlations of the expression of fibroblast growth factor-2, vascular endothelial growth factor, and their receptors with angiogenesis in synovial tissues from patients with internal derangement of the temporomandibular joint. Sato, J., Segami, N., Yoshitake, Y., Nishikawa, K. J. Dent. Res. (2003) [Pubmed]
  31. Accelerated osteoarthritis in the temporomandibular joint of biglycan/fibromodulin double-deficient mice. Wadhwa, S., Embree, M.C., Kilts, T., Young, M.F., Ameye, L.G. Osteoarthr. Cartil. (2005) [Pubmed]
  32. PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Shiojiri, T., Wada, K., Nakajima, A., Katayama, K., Shibuya, A., Kudo, C., Kadowaki, T., Mayumi, T., Yura, Y., Kamisaki, Y. Eur. J. Pharmacol. (2002) [Pubmed]
  33. Temporomandibular joint arthrography: comparison of morbidity with ionic and low osmolality contrast media. Katzberg, R.W., Miller, T.L., Hayakawa, K., Manzione, J.V., Tallents, R.H. Radiology. (1985) [Pubmed]
  34. Sex differences in amino acid release from rostral trigeminal subnucleus caudalis after acute injury to the TMJ region. Bereiter, D.A., Shen, S., Benetti, A.P. Pain (2002) [Pubmed]
  35. Development and histologic characterizations of an animal model of antigen-induced arthritis of the juvenile rabbit temporomandibular joint. Kapila, S., Lee, C., Tavakkoli Jou, M.R., Miller, A.J., Richards, D.W. J. Dent. Res. (1995) [Pubmed]
  36. Effects of temporomandibular joint stimulation on nociceptive and nonnociceptive neurons of the cat's trigeminal subnucleus caudalis (medullary dorsal horn). Broton, J.G., Hu, J.W., Sessle, B.J. J. Neurophysiol. (1988) [Pubmed]
  37. Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons. Flake, N.M., Bonebreak, D.B., Gold, M.S. J. Neurophysiol. (2005) [Pubmed]
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