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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.

CpG DNA has immunomodulatory effects, such as the suppression of allergic responses mediated by type II T cell help (T(H)2). Here we report that CpG, but not lipopolysaccharide (LPS), rapidly induces expression of T-bet mRNA in purified B cells. Up-regulation of T-bet by CpG is abrogated in mice deficient in Toll-like receptor 9 (TLR9) and MyD88, but remains intact in B cells deficient in STAT1 (signal transducer and activator of transcription 1). Interleukin 12 (IL-12) alone does not up-regulate T-bet mRNA, but greatly enhances CpG-induced T-bet expression. Furthermore, CpG inhibits immunoglobulin G1 ( IgG1) and IgE switching induced by IL-4 and CD40 signaling in purified B cells, and this effect correlates with up-regulation of T-bet. Thus, CpG triggers anti-allergic immune responses by directly regulating T-bet expression via a signaling pathway in B cells that is dependent upon TLR9, independent of interferon-gamma (IFN-gamma)-STAT1 and synergistic with IL-12.[1]


  1. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Liu, N., Ohnishi, N., Ni, L., Akira, S., Bacon, K.B. Nat. Immunol. (2003) [Pubmed]
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