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Kucharekova, M. et al.

Kucharekova, Vissers, Schalkwijk, van de Kerkhof, van der Valk,

Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation.

The exact role of epidermal fatty acid binding protein (E-FABP) in skin is unknown. A restoration of the barrier function may be associated with an upregulation of E-FABP. Moreover, E-FABP is upregulated in a variety of cells in response to oxidative stress. A recent observation that dithranol induced irritation is not associated with skin barrier impairment prompted us to investigate the expression of E-FABP in this skin condition to elucidate the unknown function of this protein in skin. This study shows lack of E-FABP upregulation after a single application of dithranol on uninvolved skin of patients with psoriasis. The expression of E-FABP in dithranol irritation correlates with the unimpaired skin barrier function as assessed by measurements of TEWL. Furthermore, we did not find evidence for the recently introduced hypothesis that E-FABP functions as an antioxidant protein in the skin irritation induced by dithranol as oxidative stressor.[1]

References

Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation. Kucharekova, M., Vissers, W.H., Schalkwijk, J.J., van de Kerkhof, P.C., van der Valk, P.G. European journal of dermatology : EJD. (2003) [Pubmed]

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