The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FABP5  -  fatty acid binding protein 5 (psoriasis...

Homo sapiens

Synonyms: E-FABP, EFABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Fatty acid-binding protein, epidermal, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FABP5

  • Maternal EFABP concentrations were significantly higher in mothers who delivered boys than in those who delivered girls [21.7 (2.3) vs 15.4 (1.7) microg/L, P = 0.028] and correlated with newborn birth weight (r = 0.266, P = 0.045) [1].
  • We studied the differential expression of mRNAs between the primary tumour samples of SCC of the oral tongue and their metastasis by differential display analysis and identified a gene, FABP5, coding for Epidermal fatty acid binding protein (E-FABP-GenBank Accession ) [2].
  • To characterize E-FABP with respect to ligand-binding properties and tertiary structure, we cloned the respective cDNA, overexpressed the protein in Escherichia coli and purified it to homogeneity by a combination of ion-exchange and size-exclusion chromatographic steps with a yield of 30 mg/L broth [3].
  • The protein comigrated with PA-FABP as determined by 2D gel analysis of [35S]-methionine-labeled proteins expressed by transformed human amnion (AMA) cells transfected with clone 1592 using the vaccinia virus expression system and reacted with a rabbit polyclonal antibody raised against 2D gel purified PA-FABP [4].
  • More interestingly, epidermal fatty acid-binding protein (E-FABP) and fatty acid-binding protein, adipocyte-type (A-FABP), were detected in liver cells but not in hepatoma cells [5].

Psychiatry related information on FABP5


High impact information on FABP5

  • Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs) [7].
  • By immunohistochemistry, we show that E-FABP is expressed in endothelial cells of the microvasculature of the placenta, heart, skeletal muscle, small intestine, lung, and renal medulla [7].
  • Interestingly, in lung, a tissue of endodermal origin, E-FABP staining was also localized to secretory cells, ie, Clara cells, goblet cells, and probably a subpopulation of pneumocytes [7].
  • RESULTS: Mean (SE) adiponectin concentrations in breast milk were 13.7 (0.8), range 3.9-30.4 microg/L; AFABP concentrations 26.7 (4.4), range 1.2-137.0 microg/L; EFABP concentrations 18.1 (1.4), range 0.8-47.0 microg/L; and leptin concentrations 0.50 (0.05), range 0-1.37 microg/L [1].
  • CONCLUSIONS: Concentrations of adiponectin, AFABP, and EFABP in human breast milk are related to nutritional variables of mothers and newborns and thus may play a role in the protective effects of breastfeeding [1].

Chemical compound and disease context of FABP5


Biological context of FABP5


Anatomical context of FABP5

  • FABP5, hsp28, and tropomyosin 9220 were also highly upregulated in quiescent keratinocytes indicating that their increased levels in the differentiated cells may be due to loss of proliferative activity [14].
  • The presence of E-FABP in tissues other than skin (heart, intestine and adipose tissue) excludes its specific role in fatty acid metabolism in epithelial cells or its involvement in skin lipid-barrier function [15].
  • Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales [16].
  • Epidermal-type fatty acid-binding protein (E-FABP), a protein related to the intracellular trafficking of fatty acids, is expressed in melanocytic tumours but not in normal human melanocytes [17].
  • In contrast, lesional psoriatic epidermis strongly expressed E-FABP in all suprabasal layers, like nonkeratinized oral mucosa [18].

Associations of FABP5 with chemical compounds


Physical interactions of FABP5


Other interactions of FABP5

  • We found a significant correlation between AFABP and EFABP concentrations (r = 0.593, P <0.0001) [1].
  • These data indicate that formation of the E-FABP-S100A7 complex and its FA-binding function might be regulated at least by bivalent cations [19].
  • All FABP types, except E-FABP, I-FABP and I-LBP interacted with 1-anilinonaphtalene-8-sulphonic acid (ANS) [23].
  • The first procedure, which is illustrated with the expression of cDNAs encoding the fatty acid binding protein 5 (FABP 5), psoriasin and stratifin, makes use of the in vitro transcription/translation assay marketed by Promega [24].
  • Additionally, E-FABP levels correlated with the amount of EpCAM in permanent squamous cell carcinoma lines and in vivo in primary head and neck carcinomas [25].

Analytical, diagnostic and therapeutic context of FABP5


  1. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Bronsky, J., Karpísek, M., Bronská, E., Pechová, M., Jancíková, B., Kotolová, H., Stejskal, D., Prusa, R., Nevoral, J. Clin. Chem. (2006) [Pubmed]
  2. Metastasis of squamous cell carcinoma of the oral tongue is associated with down-regulation of epidermal fatty acid binding protein (E-FABP). Uma, R.S., Naresh, K.N., D'Cruz, A.K., Mulherkar, R., Borges, A.M. Oral Oncol. (2007) [Pubmed]
  3. Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein. Hohoff, C., Börchers, T., Rüstow, B., Spener, F., van Tilbeurgh, H. Biochemistry (1999) [Pubmed]
  4. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. Madsen, P., Rasmussen, H.H., Leffers, H., Honoré, B., Celis, J.E. J. Invest. Dermatol. (1992) [Pubmed]
  5. Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry. Yu, L.R., Zeng, R., Shao, X.X., Wang, N., Xu, Y.H., Xia, Q.C. Electrophoresis (2000) [Pubmed]
  6. Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration. Lescuyer, P., Allard, L., Zimmermann-Ivol, C.G., Burgess, J.A., Hughes-Frutiger, S., Burkhard, P.R., Sanchez, J.C., Hochstrasser, D.F. Proteomics (2004) [Pubmed]
  7. Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein. Masouyé, I., Hagens, G., Van Kuppevelt, T.H., Madsen, P., Saurat, J.H., Veerkamp, J.H., Pepper, M.S., Siegenthaler, G. Circ. Res. (1997) [Pubmed]
  8. Expression of recombinant psoriasis-associated fatty acid binding protein in Escherichia coli: gel electrophoretic characterization, analysis of binding properties and comparison with human serum albumin. Vorum, H., Madsen, P., Svendsen, I., Cells, J.E., Honoré, B. Electrophoresis (1998) [Pubmed]
  9. Effect of a topical corticosteroid, a retinoid and a vitamin D3 derivative on sodium dodecyl sulphate induced skin irritation. Le, T.K., De Mon, P., Schalkwijk, J., van der Valk, P.G. Contact Derm. (1997) [Pubmed]
  10. Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation. Kucharekova, M., Vissers, W.H., Schalkwijk, J.J., van de Kerkhof, P.C., van der Valk, P.G. European journal of dermatology : EJD. (2003) [Pubmed]
  11. Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross. Estell??, J., P??rez-Enciso, M., Mercad??, A., Varona, L., Alves, E., S??nchez, A., Folch, J.M. Anim. Genet. (2006) [Pubmed]
  12. Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP). Gutiérrez-González, L.H., Ludwig, C., Hohoff, C., Rademacher, M., Hanhoff, T., Rüterjans, H., Spener, F., Lücke, C. Biochem. J. (2002) [Pubmed]
  13. PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. O'Shaughnessy, R.F., Seery, J.P., Celis, J.E., Frischauf, A., Watt, F.M. FEBS Lett. (2000) [Pubmed]
  14. Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Olsen, E., Rasmussen, H.H., Celis, J.E. Electrophoresis (1995) [Pubmed]
  15. Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. Siegenthaler, G., Hotz, R., Chatellard-Gruaz, D., Didierjean, L., Hellman, U., Saurat, J.H. Biochem. J. (1994) [Pubmed]
  16. Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales. Hagens, G., Roulin, K., Hotz, R., Saurat, J.H., Hellman, U., Siegenthaler, G. Mol. Cell. Biochem. (1999) [Pubmed]
  17. Urinary excretion of epidermal-type fatty acid-binding protein and S100A7 protein in patients with cutaneous melanoma. Brouard, M.C., Saurat, J.H., Ghanem, G., Siegenthaler, G. Melanoma Res. (2002) [Pubmed]
  18. Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study. Masouyé, I., Saurat, J.H., Siegenthaler, G. Dermatology (Basel) (1996) [Pubmed]
  19. Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes. Hagens, G., Masouyé, I., Augsburger, E., Hotz, R., Saurat, J.H., Siegenthaler, G. Biochem. J. (1999) [Pubmed]
  20. Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP). Siegenthaler, G., Hotz, R., Chatellard-Gruaz, D., Jaconi, S., Saurat, J.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  21. Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Lehmann, F., Haile, S., Axen, E., Medina, C., Uppenberg, J., Svensson, S., Lundbäck, T., Rondahl, L., Barf, T. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  22. Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid. Kuijpers, A.L., Bergers, M., Siegenthaler, G., Zeeuwen, P.L., van de Kerkhof, P.C., Schalkwijk, J. Acta Derm. Venereol. (1997) [Pubmed]
  23. Ligand specificity and conformational stability of human fatty acid-binding proteins. Zimmerman, A.W., van Moerkerk, H.T., Veerkamp, J.H. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  24. Expression of cDNA clones by coupled in vitro transcription/translation and transfection into COS-1 cells: protein mapping in two-dimensional gels. Madsen, P., Gromov, P., Celis, J.E. Electrophoresis (1995) [Pubmed]
  25. The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Münz, M., Zeidler, R., Gires, O. Cancer Lett. (2005) [Pubmed]
  26. Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet. Hoekstra, M., Stitzinger, M., van Wanrooij, E.J., Michon, I.N., Kruijt, J.K., Kamphorst, J., Van Eck, M., Vreugdenhil, E., Van Berkel, T.J., Kuiper, J. J. Lipid Res. (2006) [Pubmed]
WikiGenes - Universities