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Lei, Z.B. et al.

Lei, Fu, Lu, Wang, Liu, You,

Effect of estradiol on chemokine receptor CXCR2 expression in rats: implications for atherosclerosis.

AIM: To study the effect of 17beta-estradiol on expression of chemokine receptor CXCR2 in monocytes in vivo. METHODS: Expressions of chemokine receptor CXCR2 mRNA and protein were measured by RT-PCR and flow cytometry, respectively. RESULTS: In both ovary-intact and ovariectomized (OVX) rats, CXCR2 protein and mRNA expression were significantly increased in rats fed with a high-cholesterol diet for 6 weeks. The cholesterol-induced increases in CXCR2 protein and mRNA expression were significantly attenuated in OVX rats injected with estradiol-17beta (17beta-E2) (5 and 20 microg x kg(-1) x d(-1)). In normal diet rats, CXCR2 protein and mRNA expression were increased in OVX rats compared with ovary-intact rats, and this increase was prevented by 17beta-E2. CONCLUSION: Both basal and hypercholesterolemia-induced increases in chemokine receptor CXCR2 are modulated by physiological concentrations of estradiol.[1]

References

Effect of estradiol on chemokine receptor CXCR2 expression in rats: implications for atherosclerosis. Lei, Z.B., Fu, X.J., Lu, Z.T., Wang, B.C., Liu, X.L., You, N.Z. Acta Pharmacol. Sin. (2003) [Pubmed]

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