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Gene Review

Cxcr2  -  chemokine (C-X-C motif) receptor 2

Rattus norvegicus

Synonyms: C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, Cmkar2, GRO/MGSA receptor, ...
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Disease relevance of Il8rb


High impact information on Il8rb


Biological context of Il8rb

  • Chemokine receptor CXCR2 activates distinct pathways for chemotaxis and calcium mobilization [7].
  • Instead of upregulation like other chemokine receptors, interleukin-8 receptors, CXCR1and CXCR2, mRNA could not be detected in accord with the increase of interleukin-8 [8].
  • CXCR1 and CXCR2 are receptors for ELR-positive CXC chemokines which include growth-regulated oncogene alpha (GRO-alpha) and interleukin-8 (IL-8) [9].
  • Importance of the carboxy-terminus of the CXCR2 for signal transduction [10].
  • In studies of the importance of phosphorylation in CXCR2 desensitization, cells expressing wild type CXCR2 lost GTP gamma S binding above basal rate after the first exposure to IL-8, while cells with the T3 mutant retained 60% of their capacity to induce GTP gamma S exchange upon a second exposure to IL-8 [10].

Anatomical context of Il8rb

  • However, only one CINC receptor, CXCR2, has been found in rat neutrophils [7].
  • Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation [4].
  • Our results suggest that IL-8 release by glial cells in vivo may activate CXCR1 and CXCR2 receptors on cholinergic septal neurons and acutely modulate their excitability by closing calcium channels [11].
  • Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that CXCR1 mRNAs were expressed in the septum, striatum, hippocampus, cerebellum, and cortex (temporoparietal and entorhinal) at different levels and appeared to be regulated independently from CXCR2 during development [12].
  • CXCR1 and CXCR2 transcripts were colocalized in 45% of neurons sampled and also were present in some glial fibrillary acidic protein mRNA-expressing astrocytes [12].

Associations of Il8rb with chemical compounds


  1. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. Auten, R.L., Richardson, R.M., White, J.R., Mason, S.N., Vozzelli, M.A., Whorton, M.H. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  2. Contrasting roles for CXCR2 during experimental colitis. Ajuebor, M.N., Zagorski, J., Kunkel, S.L., Strieter, R.M., Hogaboam, C.M. Exp. Mol. Pathol. (2004) [Pubmed]
  3. Neutrophil chemoattractant 2 beta regulates expression of the Reg gene in injured gastric mucosa in rats. Kazumori, H., Ishihara, S., Hoshino, E., Kawashima, K., Moriyama, N., Suetsugu, H., Sato, H., Adachi, K., Fukuda, R., Watanabe, M., Takasawa, S., Okamoto, H., Fukui, H., Chiba, T., Kinoshita, Y. Gastroenterology (2000) [Pubmed]
  4. Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation. Richardson, R.M., Marjoram, R.J., Barak, L.S., Snyderman, R. J. Immunol. (2003) [Pubmed]
  5. Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells. Brack, A., Rittner, H.L., Machelska, H., Leder, K., Mousa, S.A., Schäfer, M., Stein, C. Pain (2004) [Pubmed]
  6. CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury. Vanderbilt, J.N., Mager, E.M., Allen, L., Sawa, T., Wiener-Kronish, J., Gonzalez, R., Dobbs, L.G. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  7. Chemokine receptor CXCR2 activates distinct pathways for chemotaxis and calcium mobilization. Shibata, F., Konishi, K., Nakagawa, H. Biol. Pharm. Bull. (2002) [Pubmed]
  8. Expression of chemokine and receptors in Lewis rats with experimental autoimmune anterior uveitis. Fang, I.M., Yang, C.H., Lin, C.P., Yang, C.M., Chen, M.S. Exp. Eye Res. (2004) [Pubmed]
  9. Expression of the chemokine receptors CXCR1 and CXCR2 in rat oligodendroglial cells. Nguyen, D., Stangel, M. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  10. Importance of the carboxy-terminus of the CXCR2 for signal transduction. Schraufstätter, I.U., Burger, M., Hoch, R.C., Oades, Z.G., Takamori, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  11. The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs. Puma, C., Danik, M., Quirion, R., Ramon, F., Williams, S. J. Neurochem. (2001) [Pubmed]
  12. Widely expressed transcripts for chemokine receptor CXCR1 in identified glutamatergic, gamma-aminobutyric acidergic, and cholinergic neurons and astrocytes of the rat brain: a single-cell reverse transcription-multiplex polymerase chain reaction study. Danik, M., Puma, C., Quirion, R., Williams, S. J. Neurosci. Res. (2003) [Pubmed]
  13. Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival. Limatola, C., Ciotti, M.T., Mercanti, D., Santoni, A., Eusebi, F. J. Neuroimmunol. (2002) [Pubmed]
  14. Effect of estradiol on chemokine receptor CXCR2 expression in rats: implications for atherosclerosis. Lei, Z.B., Fu, X.J., Lu, Z.T., Wang, B.C., Liu, X.L., You, N.Z. Acta Pharmacol. Sin. (2003) [Pubmed]
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