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Gene Review

Cxcl14  -  chemokine (C-X-C motif) ligand 14

Rattus norvegicus

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Disease relevance of Cxcl14


Psychiatry related information on Cxcl14


High impact information on Cxcl14


Chemical compound and disease context of Cxcl14


Biological context of Cxcl14

  • Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis [4].
  • The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors [16].
  • More specifically, fractalkine cleavage preceded actual neuronal death by 2-3 hr, and, when evaluated functionally, fractalkine represented the principal chemokine released from the neurons into the culture medium upon an excitotoxic stimulus to promote chemotaxis of primary microglial and monocytic cells [17].
  • Fractalkine is a recently identified chemokine that exhibits cell adhesion and chemoattractive properties [17].
  • Both domains of TN-R induced an up-regulation in the secretion of cytokines, such as chemokine-induced cytokine 3 and tumor neurosis factor alpha [18].

Anatomical context of Cxcl14


Associations of Cxcl14 with chemical compounds


Physical interactions of Cxcl14


Regulatory relationships of Cxcl14

  • In addition, MIP-1 alpha induced osteoclast orientation in a gradient of the chemokine, and stimulated osteoclast migration [28].
  • Ex vivo glomerular leukocytes showed decreased chemokine and chemoattractant-induced chemotaxis in response to Slit2, suggesting an anti-inflammatory role for glomerular Slit2 [29].
  • In conclusion, we demonstrated in vivo that MCP-1 is highly expressed in testicular interstitial cells suggesting that this chemokine has an important role in recruiting immune cells to the testis in rats undergoing autoimmune orchitis [30].
  • This study was designed to determine the production of the chemokine cytokine-induced neutrophil chemoattractant (CINC) by primary rat alveolar type II (ATII) cells upon stimulation with exogenous and endogenous proinflammatory factors [31].
  • These findings indicate that epithelial cells contribute to chemokine expression in rat lung after exposure to alpha-quartz and potentially other noxious particles and suggest that alpha-quartz-activated MIP-2 expression in vivo results, at least in part, from a direct action of the particles on the lung epithelium [25].

Other interactions of Cxcl14


Analytical, diagnostic and therapeutic context of Cxcl14


  1. Modulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody. Feng, L., Xia, Y., Yoshimura, T., Wilson, C.B. J. Clin. Invest. (1995) [Pubmed]
  2. Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. Colletti, L.M., Kunkel, S.L., Walz, A., Burdick, M.D., Kunkel, R.G., Wilke, C.A., Strieter, R.M. J. Clin. Invest. (1995) [Pubmed]
  3. The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury. Liu, L., Lalani, A., Dai, E., Seet, B., Macauley, C., Singh, R., Fan, L., McFadden, G., Lucas, A. J. Clin. Invest. (2000) [Pubmed]
  4. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Grady, T., Liang, P., Ernst, S.A., Logsdon, C.D. Gastroenterology (1997) [Pubmed]
  5. Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Rosi, S., Pert, C.B., Ruff, M.R., McGann-Gramling, K., Wenk, G.L. Neuroscience (2005) [Pubmed]
  6. Chronic alcohol intoxication primes Kupffer cells and endothelial cells for enhanced CC-chemokine production and concomitantly suppresses phagocytosis and chemotaxis. Bautista, A.P. Front. Biosci. (2002) [Pubmed]
  7. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Flügel, A., Berkowicz, T., Ritter, T., Labeur, M., Jenne, D.E., Li, Z., Ellwart, J.W., Willem, M., Lassmann, H., Wekerle, H. Immunity (2001) [Pubmed]
  8. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto, K., Okoshi, Y., Shibuya, K., Yamazaki, S., Tahara-Hanaoka, S., Honda, S., Osawa, M., Kuroiwa, A., Matsuda, Y., Tenen, D.G., Iwama, A., Nakauchi, H., Shibuya, A. J. Exp. Med. (2003) [Pubmed]
  9. Nerve growth cone guidance mediated by G protein-coupled receptors. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X.B., Wu, C.P., Poo, M.M., Duan, S. Nat. Neurosci. (2002) [Pubmed]
  10. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. Johnston, B., Burns, A.R., Suematsu, M., Issekutz, T.B., Woodman, R.C., Kubes, P. J. Clin. Invest. (1999) [Pubmed]
  11. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Twu, C., Liu, N.Q., Popik, W., Bukrinsky, M., Sayre, J., Roberts, J., Rania, S., Bramhandam, V., Roos, K.P., MacLellan, W.R., Fiala, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation. Haddad, e.l.-.B., McCluskie, K., Birrell, M.A., Dabrowski, D., Pecoraro, M., Underwood, S., Chen, B., De Sanctis, G.T., Webber, S.E., Foster, M.L., Belvisi, M.G. J. Immunol. (2002) [Pubmed]
  13. Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production. Uehara, T., Matsuno, J., Kaneko, M., Nishiya, T., Fujimuro, M., Yokosawa, H., Nomura, Y. J. Biol. Chem. (1999) [Pubmed]
  14. L-arginine suppresses lipopolysaccharide-induced expression of RANTES in glomeruli. Haberstroh, U., Stilo, K., Pocock, J., Wolf, G., Helmchen, U., Wenzel, U., Zahner, G., Stahl, R.A., Thaiss, F. J. Am. Soc. Nephrol. (1998) [Pubmed]
  15. In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats. Ohsawa, I., Murakami, T., Uemoto, S., Kobayashi, E. Transplantation (2006) [Pubmed]
  16. The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors. Limatola, C., Ciotti, M.T., Mercanti, D., Vacca, F., Ragozzino, D., Giovannelli, A., Santoni, A., Eusebi, F., Miledi, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  17. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. Chapman, G.A., Moores, K., Harrison, D., Campbell, C.A., Stewart, B.R., Strijbos, P.J. J. Neurosci. (2000) [Pubmed]
  18. Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function. Liao, H., Bu, W.Y., Wang, T.H., Ahmed, S., Xiao, Z.C. J. Biol. Chem. (2005) [Pubmed]
  19. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Harrison, J.K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R.K., Streit, W.J., Salafranca, M.N., Adhikari, S., Thompson, D.A., Botti, P., Bacon, K.B., Feng, L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. Ohno, Y., Lee, J., Fusunyan, R.D., MacDermott, R.P., Sanderson, I.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. Larbi, K.Y., Allen, A.R., Tam, F.W., Haskard, D.O., Lobb, R.R., Silva, P.M., Nourshargh, S. Blood (2000) [Pubmed]
  22. The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Burdon, P.C., Martin, C., Rankin, S.M. Blood (2005) [Pubmed]
  23. Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. Paul-Clark, M.J., Mancini, L., Del Soldato, P., Flower, R.J., Perretti, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  24. The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4. Callewaere, C., Banisadr, G., Desarménien, M.G., Mechighel, P., Kitabgi, P., Rostène, W.H., Mélik Parsadaniantz, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  25. Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure. Driscoll, K.E., Howard, B.W., Carter, J.M., Asquith, T., Johnston, C., Detilleux, P., Kunkel, S.L., Isfort, R.J. Am. J. Pathol. (1996) [Pubmed]
  26. Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. Tailor, A., Tomlinson, A., Salas, A., Panés, J., Granger, D.N., Flower, R.J., Perretti, M. Gut (1999) [Pubmed]
  27. Characterization of relapsing autoimmune encephalomyelitis and its treatment with decoy chemokine receptor genes. Matsumo, Y., Sakuma, H., Miyakoshi, A., Tsukada, Y., Kohyama, K., Park, I.K., Tanuma, N. J. Neuroimmunol. (2005) [Pubmed]
  28. Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts. Fuller, K., Owens, J.M., Chambers, T.J. J. Immunol. (1995) [Pubmed]
  29. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Kanellis, J., Garcia, G.E., Li, P., Parra, G., Wilson, C.B., Rao, Y., Han, S., Smith, C.W., Johnson, R.J., Wu, J.Y., Feng, L. Am. J. Pathol. (2004) [Pubmed]
  30. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. Guazzone, V.A., Rival, C., Denduchis, B., Lustig, L. J. Reprod. Immunol. (2003) [Pubmed]
  31. Cytokine-induced neutrophil chemoattractant production by primary rat alveolar type II cells. Crippen, T.L., Klasing, K.C., Hyde, D.M. Inflammation (1995) [Pubmed]
  32. Neuronal MCP-1 expression in response to remote nerve injury. Flügel, A., Hager, G., Horvat, A., Spitzer, C., Singer, G.M., Graeber, M.B., Kreutzberg, G.W., Schwaiger, F.W. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  33. Effect of cold-ischemia time on C-X-C chemokine expression and neutrophil accumulation in the graft liver after orthotopic liver transplantation in rats. Kataoka, M., Shimizu, H., Mitsuhashi, N., Ohtsuka, M., Wakabayashi, Y., Ito, H., Kimura, F., Nakagawa, K., Yoshidome, H., Shimizu, Y., Miyazaki, M. Transplantation (2002) [Pubmed]
  34. Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. Liu, D., Cardozo, A.K., Darville, M.I., Eizirik, D.L. Endocrinology (2002) [Pubmed]
  35. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Wenzel, U., Schneider, A., Valente, A.J., Abboud, H.E., Thaiss, F., Helmchen, U.M., Stahl, R.A. Kidney Int. (1997) [Pubmed]
  36. Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Ondeykal, J.G., Herath, K.B., Jayasuriya, H., Polishook, J.D., Bills, G.F., Dombrowski, A.W., Mojena, M., Koch, G., DiSalvo, J., DeMartino, J., Guan, Z., Nanakorn, W., Morenberg, C.M., Balick, M.J., Stevenson, D.W., Slattery, M., Borris, R.P., Singh, S.B. Mol. Divers. (2005) [Pubmed]
  37. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. Youssef, S., Maor, G., Wildbaum, G., Grabie, N., Gour-Lavie, A., Karin, N. J. Clin. Invest. (2000) [Pubmed]
  38. In vitro and in vivo dependency of chemokine generation on C5a and TNF-alpha. Czermak, B.J., Sarma, V., Bless, N.M., Schmal, H., Friedl, H.P., Ward, P.A. J. Immunol. (1999) [Pubmed]
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