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Pearson, A.M. et al.

Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila.

Phagocytosis is a complex and apparently evolutionarily conserved process that plays a central role in the immune response to infection. By ultrastructural and functional criteria, Drosophila hemocyte (macrophage) phagocytosis resembles mammalian phagocytosis. Using a non-saturated forward genetic screen for larval hemocyte phagocytosis mutants, D-SCAR and profilin were identified as important regulators of phagocytosis in Drosophila. In both hemocytes ex vivo and the macrophage-like S2 cell line, lack of D-SCAR significantly decreased phagocytosis of Escherichia coli and Staphylococcus aureus. In contrast, profilin mutant hemocytes exhibited increased phagocytic activity. Analysis of double mutants suggests that D-SCAR and profilin interact during phagocytosis. Finally, RNA interference studies in S2 cells indicated that the D-SCAR homolog D-WASp also participates in phagocytosis. This study demonstrates that Drosophila provides a viable model system in which to dissect the complex interactions that regulate phagocytosis.[1]

References

Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Pearson, A.M., Baksa, K., Rämet, M., Protas, M., McKee, M., Brown, D., Ezekowitz, R.A. Microbes Infect. (2003) [Pubmed]

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