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Gene Review

SCAR  -  CG4636 gene product from transcript CG4636-RD

Drosophila melanogaster

Synonyms: BEST:SD02991, CG4636, D-SCAR, DWave, DmSCAR, ...
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Disease relevance of SCAR


High impact information on SCAR

  • Late in larval development, as differentiation and patterning begin, the retinal epithelium exhibits striking regulation of the cell cycle including a transient G1 arrest of all cells, followed by a "Second Mitotic Wave" cell cycle that is regulated at the G2/M transition by local intercellular signals [2].
  • Finally, RNA interference studies in S2 cells indicated that the D-SCAR homolog D-WASp also participates in phagocytosis [1].
  • Analysis of double mutants suggests that D-SCAR and profilin interact during phagocytosis [1].


  1. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Pearson, A.M., Baksa, K., Rämet, M., Protas, M., McKee, M., Brown, D., Ezekowitz, R.A. Microbes Infect. (2003) [Pubmed]
  2. Cell proliferation, survival, and death in the Drosophila eye. Baker, N.E. Semin. Cell Dev. Biol. (2001) [Pubmed]
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