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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The antimicrobial efficacy of ' MGP' gutta-percha in vitro.

AIM: To determine whether ' MGP' gutta-percha (Westport, CT, USA), a commercially available gutta-percha containing iodoform, inhibits the growth of potential endodontic pathogens. METHODOLOGY: Inocula of Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus sanguis, Fusobacterium nucleatum and Actinomyces odontolyticus were spread onto the surface of agar plates. ' MGP' gutta-percha cones presoaked in sterile water were transferred to the inoculated agar and incubated at 37 degrees C aerobically or anaerobically as required for optimal growth. Identical studies were performed using iodoform-free gutta-percha and sterile paper disks saturated with 10% povidone-iodine. Following incubation, zones of inhibition around the ' MGP' gutta-percha, iodoform-free gutta-percha and disks were evaluated. RESULTS: Povidone-iodine inhibited all the strains. Iodoform-free gutta-percha inhibited S. sanguis and A. odontolyticus. ' MGP' gutta-percha inhibited S. aureus, S. sanguis, A. odontolyticus and F. nucleatum. Neither iodoform-free gutta-percha nor ' MGP' gutta-percha inhibited growth of E. faecalis, E. coli or P. aeruginosa. CONCLUSIONS: Compared to iodoform-free gutta-percha, iodoform-containing ' MGP' gutta-percha had an inhibitory effect in vitro on S. aureus and F. nucleatum, but not on E. faecalis, E. coli or P. aeruginosa.[1]


  1. The antimicrobial efficacy of 'MGP' gutta-percha in vitro. Shur, A.L., Sedgley, C.M., Fenno, J.C. International endodontic journal. (2003) [Pubmed]
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