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Chemical Compound Review

IODOFORM     triiodomethane

Synonyms: Jodoform, Trijodmethane, Triiodomethane, Dezinfekt V, Iodoform (TN), ...
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Disease relevance of iodoform


High impact information on iodoform

  • The SPME-TPD technique was applied to the determination of iodination disinfection byproducts from individual precursor compounds using GC/MS and to the quantitation of iodoform at trace levels in a water recycle system using GC/ECD [6].
  • On MR, calcium sodium alginate and bismuth and iodoform paraffin paste had imaging characteristics similar to muscle and aqueous betadine gauze had appearances similar to bone marrow [7].
  • During presurgical investigation a radiodense mass was detected in the left nasal cavity, which turned out to be an iodoform-soaked gauze pack put in by a general practitioner some weeks previously and simply forgotten [8].
  • The experimental group contained six different types of root canal filling materials, including zinc oxide (ZnO) + eugenol + formocresol (FC), Ca(OH)(2) + FC, Ca(OH)(2) + Iodoform, Ca(OH)(2) + Iodoform + camphorated parachlorophenol (CPC), Ca(OH)(2) + CPC, and Vitapex [9].
  • The Ca(OH)(2) + Iodoform group and Vitapex group showed the highest survival rates (p < 0.05) [9].

Chemical compound and disease context of iodoform

  • PATIENTS AND METHODS: Forty HIV positive patients with CD4 counts below 200cells/mm(3) who were to have molar teeth extracted were randomly allocated to have the socket dressed with a medicated paste (Rifocort((R)) with camphorated parachlorophenol and iodoform) and sutured (treated group), or merely sutured (control group) [10].
  • A prospective study was undertaken to compare the efficacy of Merocel nasal tampons to BIPP (Bismuth Subnitrate and Iodoform Paste) impregnated ribbon gauze in the control of acute epistaxis requiring hospital admission [11].

Biological context of iodoform


Anatomical context of iodoform

  • Elimination of infection in pulpectomized deciduous teeth: a short-term study using iodoform paste [13].
  • Root canal filling with a slowly resorbable iodoform paste in the apical part: report of a long term follow up [14].
  • The surgical procedure is a modification of the maxillary sinus approach, which includes the use of iodoform gauze packing, nasal antrostomy, a double layer oral closure and prophylactic antibiotics [15].
  • Reactions of subcutaneous connective tissue and incised wounds to strips of petrolatum or iodoform gauzes [16].
  • Of 78 necrotic primary molars, 34 were filled with ZOE and 44 with an iodoform-containing paste (KRI) [17].

Associations of iodoform with other chemical compounds

  • Thermal degradation of iodoform was observed during desorption from a polyacrylate fiber in initial GC/MS and GC/ECD experiments [6].
  • The results showed that the pH ranged from a low of 2.90 +/- 0.02 for iodoform paste (Kri) to a high of 12.45 +/- 0.02 for calcium hydroxide (Calyxl) [18].
  • Medicaments such as formocresol, eugenol and iodoform pastes have been extensively used for endodontic therapy yet very little attention has been given to their pH values.(ABSTRACT TRUNCATED AT 250 WORDS)[18]
  • The Ca(OH)(2) + Iodoform + CPC group and Ca(OH)(2) + CPC group showed significantly lower survival rates at concentrations above 6 muL/mL (p < 0.05) [9].
  • In this study we investigated the effect of four medicaments -- BIPP, (bismuth iodoform paraffin paste), Whitehead's varnish (compound iodoform paint), Surgicel (oxidized regenerated cellulose) and Carnoy's solution (ethanol, chloroform and acetic acid) -- on peripheral nerve function [19].

Gene context of iodoform

  • Following incubation, zones of inhibition around the 'MGP' gutta-percha, iodoform-free gutta-percha and disks were evaluated [20].

Analytical, diagnostic and therapeutic context of iodoform


  1. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Weber, L.W., Boll, M., Stampfl, A. Crit. Rev. Toxicol. (2003) [Pubmed]
  2. Carcinogenicity studies on halogenated hydrocarbons. Weisburger, E.K. Environ. Health Perspect. (1977) [Pubmed]
  3. Suspected toxicity from an iodoform preparation in a diabetic patient with multiple foot ulcers. Matsumura, Y., Tsuji, A., Izawa, J., Kumakura, A., Hiramatsu, M., Kogo, K., Takahashi, K., Inoue, Y., Harada, H., Tonozuka, N. Diabet. Med. (2005) [Pubmed]
  4. Allergic contact stomatitis and cheilitis from iodoform used in a dental dressing. Maurice, P.D., Hopper, C., Punnia-Moorthy, A., Rycroft, R.J. Contact Derm. (1988) [Pubmed]
  5. Allergic contact otitis externa due to iodoform in BIPP cavity dressings. Roest, M.A., Shaw, S., Orton, D.I. Contact Derm. (2002) [Pubmed]
  6. Solid-phase microextraction with temperature-programmed desorption for the analysis of iodination disinfection byproducts. Frazey, P.A., Barkley, R.M., Sievers, R.E. Anal. Chem. (1998) [Pubmed]
  7. CT and MR appearance of otolaryngologic packing materials. Hartley, C., Ng, K.L., Jackson, A. AJNR. American journal of neuroradiology. (1995) [Pubmed]
  8. Radiology of a rare foreign body in the nasal cavity. Schoendorf, J., Jungehuelsing, M. Neuroradiology. (2000) [Pubmed]
  9. Biocompatibility of various formula root filling materials for primary teeth. Huang, T.H., Ding, S.J., Kao, C.T. J. Biomed. Mater. Res. Part B Appl. Biomater. (2007) [Pubmed]
  10. Effect of a topical antimicrobial paste on healing after extraction of molars in HIV positive patients: Randomised controlled clinical trial. Ortega, K.L., Rezende, N.P., Ara??jo, N.S., Magalh??es, M.H. The British journal of oral & maxillofacial surgery (2007) [Pubmed]
  11. A prospective randomized controlled trial comparing the use of merocel nasal tampons and BIPP in the control of acute epistaxis. Corbridge, R.J., Djazaeri, B., Hellier, W.P., Hadley, J. Clinical otolaryngology and allied sciences. (1995) [Pubmed]
  12. Subacute inhalation toxicity testing with iodoform vapor. Tansy, M.F., Werley, M., Landin, W., Oberly, R., Kendall, F.M., Miller, A., Sherman, W. Journal of toxicology and environmental health. (1981) [Pubmed]
  13. Elimination of infection in pulpectomized deciduous teeth: a short-term study using iodoform paste. Thomas, A.M., Chandra, S., Chandra, S., Pandey, R.K. Journal of endodontics. (1994) [Pubmed]
  14. Root canal filling with a slowly resorbable iodoform paste in the apical part: report of a long term follow up. Tagger, M. Refuʾat ha-shinayim (Tel Aviv, Israel : 1983) (1985) [Pubmed]
  15. A retrospective study of treatment of orbital floor fractures with the maxillary sinus approach. Gray, L.N., Kalimuthu, R., Jayaram, B., Lewis, N., Sohaey, M. British journal of plastic surgery. (1985) [Pubmed]
  16. Reactions of subcutaneous connective tissue and incised wounds to strips of petrolatum or iodoform gauzes. de Carvalho, A.C., Okamoto, T., Callestini, E.A., Sanches, M.G., de Carvalho, P.S. Revista da Faculdade de Odontologia de Araçatuba. (1978) [Pubmed]
  17. A comparison of pulpectomies using ZOE and KRI paste in primary molars: a retrospective study. Holan, G., Fuks, A.B. Pediatric dentistry. (1993) [Pubmed]
  18. PH of endodontic medicaments used in pediatric dentistry: effects of dyadic combinations. Anderson, M., Seow, W.K. The Journal of clinical pediatric dentistry. (1990) [Pubmed]
  19. The effect of surgical medicaments on peripheral nerve function. Loescher, A.R., Robinson, P.P. The British journal of oral & maxillofacial surgery. (1998) [Pubmed]
  20. The antimicrobial efficacy of 'MGP' gutta-percha in vitro. Shur, A.L., Sedgley, C.M., Fenno, J.C. International endodontic journal. (2003) [Pubmed]
  21. Current and potential pulp therapies for primary and young permanent teeth. Ranly, D.M., Garcia-Godoy, F. Journal of dentistry. (2000) [Pubmed]
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