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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Social isolation does not alter brain regional benzodiazepine binding site numbers, affinity and coupling in the rat.

Male Sprague-Dawley rats were differentially housed for 21 days immediately after weaning. Isolated animals showed a selective suppression of exploration of the light side of a two compartment box; spending significantly less time in the light, and making fewer transitions between the light and dark compartments compared to socially reared controls. However, both basal and GABA-stimulated [3H] flunitrazepam binding was unaltered in the frontal cortex, hippocampus, amygdala and cerebellum following social isolation. These results are discussed in relation to other studies on central benzodiazepine receptor changes following a variety of experimental stressors.[1]

References

  1. Social isolation does not alter brain regional benzodiazepine binding site numbers, affinity and coupling in the rat. Morinan, A., Parker, V., Rich, D.A., Cariuk, P., Horton, R.W. Psychopharmacology (Berl.) (1992) [Pubmed]
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