The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Use of ameroid constrictors in the development of renin-dependent hypertension in dogs.

We describe methods for using ameroid constrictors to develop renin-dependent hypertension in dogs. A vascular-access-port was implanted in each dog and mean arterial blood pressure was monitored. Via a small flank incision, an ameroid constrictor was placed on the left renal artery and mean arterial blood pressure, plasma renin activity, and the response to angiotensin-converting enzyme inhibition measured during the subsequent 4 weeks. Placement of the constrictor on the left renal artery resulted in a significant increase in plasma renin activity which was accompanied by a significant hypertension (blood pressure greater than 140 mmHg). The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.). The results of this study indicate that ameroid constrictors provide a reliable method for establishing renin-dependent hypertension in dogs.[1]

References

 
WikiGenes - Universities