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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gene order and genetic distance of 13 loci spanning murine chromosome 15.

Thirteen genetic loci spanning murine chromosome 15 from 15A2 (Mlvi-2) to 15F2-3 (Gdc-1) have been mapped. The genetic distance extends to 55.4 cM. Among 151 animals, only 1 animal with a double cross-over was found. The linear order is unambiguous, with the exception of the distal end on 15F1-3. Our analysis favors the order cen-Ela-1/Hox-3-Wnt-1-Gdc-1-ter. This ordering makes necessary the introduction of three tightly spaced double recombination events around and within the Hox-3 locus. Alternatively, Hox-3 may be most distal, and several double recombinations at the telomere lead to map expansion. Despite the unequal distribution along chromosome 15 of G-versus R-bands, a comparison of distances determined by physical and genetic mapping does not indicate an overt difference in distance between both mapping techniques.[1]


  1. Gene order and genetic distance of 13 loci spanning murine chromosome 15. Hameister, H., Schulz, W.A., Meyer, J., Thoma, S., Adolph, S., Gaa, A., von Deimling, O. Genomics (1992) [Pubmed]
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