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Gene Review

Hoxc  -  homeobox C cluster

Mus musculus

Synonyms: Hox-3, Hox-6
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Disease relevance of Hoxc


High impact information on Hoxc


Biological context of Hoxc


Anatomical context of Hoxc

  • Hoxc family transcription factors are expressed in different domains along the rostrocaudal (RC) axis of the developing spinal cord and they define RC identities of spinal neurons [12].
  • Our previous study using an in vitro assay system demonstrated that Fgf and Gdf11 signals located around Hensen's node of chick embryos have the ability to induce profiled Hoxc protein expression [12].
  • These data suggest a specific role for the AbdB-related Hoxc genes in patterning the hindlimb and pelvic girdle, which is separate from a second role relevant for both hind- and forelimb development [13].
  • The anterior boundaries of Hox-3.5 expression in the hindbrain and prevertebral column lie anterior to those of Hox-3.4 and all other, more 5'-located Hox-3 genes [14].

Other interactions of Hoxc

  • The murine homeobox-containing gene Hox-3.2 is the most 5' member of the Hox-3 complex on chromosome 15 isolated to date [15].
  • Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster [16].
  • As a prerequisite for studying the role of the AbdB-related Hoxc genes during limb development, we have isolated and mapped the three predicted AbdB-related Hoxc-11, -12, and -13 loci, thus defining the 5' end of the Hoxc cluster [13].


  1. Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid. Mavilio, F., Simeone, A., Boncinelli, E., Andrews, P.W. Differentiation (1988) [Pubmed]
  2. Spatial restriction in expression of a mouse homoeo box locus within the central nervous system. Awgulewitsch, A., Utset, M.F., Hart, C.P., McGinnis, W., Ruddle, F.H. Nature (1986) [Pubmed]
  3. The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts. Njølstad, P.R., Molven, A., Apold, J., Fjose, A. EMBO J. (1990) [Pubmed]
  4. Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. Breier, G., Dressler, G.R., Gruss, P. EMBO J. (1988) [Pubmed]
  5. The evolution of the vertebrate Dlx gene family. Stock, D.W., Ellies, D.L., Zhao, Z., Ekker, M., Ruddle, F.H., Weiss, K.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. Cannizzaro, L.A., Croce, C.M., Griffin, C.A., Simeone, A., Boncinelli, E., Huebner, K. Am. J. Hum. Genet. (1987) [Pubmed]
  7. Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Amores, A., Suzuki, T., Yan, Y.L., Pomeroy, J., Singer, A., Amemiya, C., Postlethwait, J.H. Genome Res. (2004) [Pubmed]
  8. Gene order and genetic distance of 13 loci spanning murine chromosome 15. Hameister, H., Schulz, W.A., Meyer, J., Thoma, S., Adolph, S., Gaa, A., von Deimling, O. Genomics (1992) [Pubmed]
  9. Coding sequence and expression of the homeobox gene Hox 1.3. Fibi, M., Zink, B., Kessel, M., Colberg-Poley, A.M., Labeit, S., Lehrach, H., Gruss, P. Development (1988) [Pubmed]
  10. Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Gaufo, G.O., Thomas, K.R., Capecchi, M.R. Development (2003) [Pubmed]
  11. Isolation and expression of a new mouse homeobox gene. Sharpe, P.T., Miller, J.R., Evans, E.P., Burtenshaw, M.D., Gaunt, S.J. Development (1988) [Pubmed]
  12. The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord. Liu, J.P. Development (2006) [Pubmed]
  13. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Peterson, R.L., Papenbrock, T., Davda, M.M., Awgulewitsch, A. Mech. Dev. (1994) [Pubmed]
  14. Sequence and embryonic expression of the murine Hox-3.5 gene. Geada, A.M., Gaunt, S.J., Azzawi, M., Shimeld, S.M., Pearce, J., Sharpe, P.T. Development (1992) [Pubmed]
  15. Structure and expression pattern of the murine Hox-3.2 gene. Erselius, J.R., Goulding, M.D., Gruss, P. Development (1990) [Pubmed]
  16. Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster. Peterson, R.L., Jacobs, D.F., Awgulewitsch, A. Mech. Dev. (1992) [Pubmed]
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