Disease relevance of Mlvi2

• Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15 [1].
• Because sequences homologous to at least three of these regions (Mlvi-1, Mlvi-2, and c-myc) map to chromosome 15 in the mouse, the question was raised whether they are closely linked in the rat genome and whether provirus integration in any one of these regions affects the same functional domain in rat DNA [2].
• The chromosomal map location of Mlvi-1 to chromosome 7 and Mlvi-2 to chromosome 2 is interesting, since chromosomal aberrations involving these two chromosomes are reproducibly observed in rat neoplasias induced by a variety of agents [2].

High impact information on Mlvi2

• We conclude that Mlvi-1, Mlvi-2, and Mlvi-3 are separate and independent genetic loci [2].
• Thirteen genetic loci spanning murine chromosome 15 from 15A2 (Mlvi-2) to 15F2-3 (Gdc-1) have been mapped [3].
• Localization of a Moloney murine leukemia virus integration site gene, Mlvi2, on rat chromosome 2 [4].
• In Mlvi-2 we have shown the presence of a transcribed region downstream from the cluster of the integrated proviruses in the MoMuLV induced thymic lymphomas [5].

Other interactions of Mlvi2

• A co-distribution of PV-RFLPs with Pvt-1 and Mlvi-2, which had been localized on chromosome 15, was detected [6].

References