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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats.

BACKGROUND: Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS: The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula graft model. After transplantation, the recipient rats were treated with vehicle, low-dose cerivastatin, high-dose cerivastatin, or cyclosporine A. RESULTS: Transplanted bones treated with low-dose cerivastatin and vehicle failed to unite with the recipient bones. In contrast, high-dose cerivastatin induced the bone union as effectively as cyclosporine A. Histologically, high-dose cerivastatin-treated transplanted bones were nonvital, but new bone formation occurred at the outer layer of the nonvital cortex. CONCLUSION: These results indicate that statins could promote fracture healing. Because transplant recipients have the increased risks of osteoporotic fracture and hypercholesterolemia, statins may be a good choice in the treatment of these patients.[1]

References

  1. Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats. Ohno, T., Shigetomi, M., Ihara, K., Matsunaga, T., Hashimoto, T., Kawano, H., Sugiyama, T., Kawai, S. Transplantation (2003) [Pubmed]
 
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