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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intestinal amino acid and monosaccharide transport in suckling pigs fed milk replacers with different sources of carbohydrate.

Omnivorous mammals are able to adaptively modulate rates of intestinal nutrient transport to match changes in diet. Because adaptive responses during suckling, when dietary composition is relatively constant, have not been adequately determined, we measured in vitro sugar and amino acid uptake [nmol/(mg tissue.min)] in suckling pigs fed milk replacers with either lactose (LAC) or a 60:40 mixture of maltodextrin and sucrose (MDS). The MDS-fed pigs initially grew slower, but had intestinal dimensions similar to those of LAC-fed siblings when normalized to body weight. Carrier-mediated uptake for three monosaccharides (glucose, galactose, fructose) did not differ between LAC- and MDS-fed pigs at 5, 10, 15 and 20 d of age. Interdiet differences in rates of leucine and proline uptake, despite identical types and concentration of protein in both milk replacers, are indicative of non-specific responses to diet during suckling. Uptake capacities (grams of monosaccharide absorbed per 24 h) never exceeded estimates of monosaccharide intake by more than fourfold and were less than aldohexose intake during early suckling. Our results indicate 1) age-related changes in rates of nutrient uptake are genetically programmed and little influenced by diet; 2) any responses to diet are nonspecific and likely involve a shift in the timing of the genetic program; and 3) at birth and throughout suckling, pigs are capable of absorbing limited quantities of alternative nutrients.[1]


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