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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Mitotic mechanics: the auroras come into view.

Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.[1]

References

  1. Mitotic mechanics: the auroras come into view. Andrews, P.D., Knatko, E., Moore, W.J., Swedlow, J.R. Curr. Opin. Cell Biol. (2003) [Pubmed]
 
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