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Gene Review

ial  -  IplI-aurora-like kinase

Drosophila melanogaster

Synonyms: ABK, Aur B, AurB, Aurora B, Aurora kinase B, ...
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High impact information on ial

  • Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics [1].
  • In contrast, peripheral MTs still probe the cortex and form regions of overlap that recruit the Pav-KLP motor and Aurora B kinase. orbit mutants have disorganized or incomplete anillin and actin rings, and although cleavage furrows initiate, they ultimately regress [2].
  • This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis [3].
  • We provide evidence that Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability [4].
  • These experiments reveal that INCENP is required for aurora B kinase function and confirm that the chromosomal passengers have essential roles in mitosis [5].

Biological context of ial

  • Given its established role in destabilizing kinetochore-microtubule interactions [3], Aurora B dissociation is likely to be key to the change in kinetochore behavior [6].
  • A MEI-S332 mutant that is only poorly phosphorylated by Aurora B is defective in localization to centromeres [7].
  • INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila [7].
  • The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial [8].
  • Characterization of spatial and temporal expression of ial and its gene product showed that it manifests itself in patterns which can be consistent with a role in cell cycle control [9].

Anatomical context of ial


Associations of ial with chemical compounds


Enzymatic interactions of ial


Other interactions of ial


Analytical, diagnostic and therapeutic context of ial

  • Dissection of the Aurora B pathway, where we found a new gene and a specific small molecule inhibitor, should benefit particularly [13].


  1. Mitotic mechanics: the auroras come into view. Andrews, P.D., Knatko, E., Moore, W.J., Swedlow, J.R. Curr. Opin. Cell Biol. (2003) [Pubmed]
  2. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. Inoue, Y.H., Savoian, M.S., Suzuki, T., Máthé, E., Yamamoto, M.T., Glover, D.M. J. Cell Biol. (2004) [Pubmed]
  3. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. Bucciarelli, E., Giansanti, M.G., Bonaccorsi, S., Gatti, M. J. Cell Biol. (2003) [Pubmed]
  4. Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. Lange, B.M., Rebollo, E., Herold, A., González, C. EMBO J. (2002) [Pubmed]
  5. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. Adams, R.R., Maiato, H., Earnshaw, W.C., Carmena, M. J. Cell Biol. (2001) [Pubmed]
  6. Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Parry, D.H., Hickson, G.R., O'Farrell, P.H. Curr. Biol. (2003) [Pubmed]
  7. INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Resnick, T.D., Satinover, D.L., MacIsaac, F., Stukenberg, P.T., Earnshaw, W.C., Orr-Weaver, T.L., Carmena, M. Dev. Cell (2006) [Pubmed]
  8. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Mesilaty-Gross, S., Reich, A., Motro, B., Wides, R. Gene (1999) [Pubmed]
  9. Cloning, mapping, and expression of ial, a novel Drosophila member of the Ipl1/aurora mitotic control kinase family. Reich, A., Yanai, A., Mesilaty-Gross, S., Chen-Moses, A., Wides, R., Motro, B. DNA Cell Biol. (1999) [Pubmed]
  10. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. Giet, R., Glover, D.M. J. Cell Biol. (2001) [Pubmed]
  11. Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Hanson, K.K., Kelley, A.C., Bienz, M. Development (2005) [Pubmed]
  12. Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Goto, H., Yasui, Y., Nigg, E.A., Inagaki, M. Genes Cells (2002) [Pubmed]
  13. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. Eggert, U.S., Kiger, A.A., Richter, C., Perlman, Z.E., Perrimon, N., Mitchison, T.J., Field, C.M. PLoS Biol. (2004) [Pubmed]
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