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Gene Review

aur  -  aurora

Drosophila melanogaster

Synonyms: 87A7-9/2, Aur-A, AurA, CG3068, Dmel\CG3068, ...
 
 
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High impact information on aur

  • Syncytial embryos derived from aur mothers display closely paired centrosomes at inappropriate mitotic stages and develop interconnected spindles in which the poles are shared [1].
  • We show that female sterile mutations of aurora (aur) are allelic to mutations in the lethal complementation group ck10 [1].
  • A 250 bp region upstream of both aur and a divergent transcription unit corresponds to the site of a specific chromatin structure (scs') previously proposed to be a barrier to insulate enhancers of the major hsp70 gene at 87A7 [1].
  • Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division [2].
  • Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation [3].
 

Biological context of aur

 

Anatomical context of aur

  • Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules [8].
  • Disruption of the function of the A-type Aurora kinase of Drosophila by mutation or RNAi leads to a reduction in the length of astral microtubules in syncytial embryos, larval neuroblasts, and cultured S2 cells [8].
  • By using a two-hybrid screen, we have identified maskin, a protein involved in the control of mRNA sequential translation, as a binding partner of Aurora-A, a protein kinase necessary for oocyte maturation [5].
  • We demonstrated that suppression of Aurora-A by small interfering RNA caused multiple events to fail in mitosis, such as incorrect separation of centriole pairs, misalignment of chromosomes on the metaphase plate, and incomplete cytokinesis [9].
 

Associations of aur with chemical compounds

 

Physical interactions of aur

  • We show that a subpopulation of the total Aurora A is present in a complex with D-TACC, which is a substrate for the kinase [8].
 

Enzymatic interactions of aur

 

Other interactions of aur

  • Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells [11].
  • Genes for the mitotic kinases Polo and Aurora A were first identified in Drosophila through screens of maternal effect lethal mutations for defects in spindle pole behaviour [12].
 

Analytical, diagnostic and therapeutic context of aur

  • Here, we have investigated the roles of Aurora-A in mitotic progression with the small interfering RNA, antibody microinjection, and time lapse microscopy using human cells [9].

References

  1. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Glover, D.M., Leibowitz, M.H., McLean, D.A., Parry, H. Cell (1995) [Pubmed]
  2. Mitotic mechanics: the auroras come into view. Andrews, P.D., Knatko, E., Moore, W.J., Swedlow, J.R. Curr. Opin. Cell Biol. (2003) [Pubmed]
  3. Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Lee, C.Y., Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., Doe, C.Q. Genes Dev. (2006) [Pubmed]
  4. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Berdnik, D., Knoblich, J.A. Curr. Biol. (2002) [Pubmed]
  5. Phosphorylation of maskin by Aurora-A participates in the control of sequential protein synthesis during Xenopus laevis oocyte maturation. Pascreau, G., Delcros, J.G., Cremet, J.Y., Prigent, C., Arlot-Bonnemains, Y. J. Biol. Chem. (2005) [Pubmed]
  6. The Aurora kinases: role in cell transformation and tumorigenesis. Katayama, H., Brinkley, W.R., Sen, S. Cancer Metastasis Rev. (2003) [Pubmed]
  7. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Stenoien, D.L., Sen, S., Mancini, M.A., Brinkley, B.R. Cell Motil. Cytoskeleton (2003) [Pubmed]
  8. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. Giet, R., McLean, D., Descamps, S., Lee, M.J., Raff, J.W., Prigent, C., Glover, D.M. J. Cell Biol. (2002) [Pubmed]
  9. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. Marumoto, T., Honda, S., Hara, T., Nitta, M., Hirota, T., Kohmura, E., Saya, H. J. Biol. Chem. (2003) [Pubmed]
  10. A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos. Schumacher, J.M., Ashcroft, N., Donovan, P.J., Golden, A. Development (1998) [Pubmed]
  11. Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. Terada, Y., Uetake, Y., Kuriyama, R. J. Cell Biol. (2003) [Pubmed]
  12. Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles. Glover, D.M. Oncogene (2005) [Pubmed]
 
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