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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

STAT4 is required for interleukin-12- induced chromatin remodeling of the CD25 locus.

Signal transducer and activator of transcription 4 (STAT4) is a critical mediator of interleukin-12 (IL-12)-stimulated inflammatory immune responses. Despite extensive analysis of the immune responses of STAT4-deficient mice, there is still very little understood about STAT4-dependent gene induction. IL-12 stimulated increases in IL-2 receptor alpha chain gene (CD25) mRNA levels and surface expression require STAT4. In this report, we utilize chromatin immunoprecipitation assays to analyze IL-12-stimulated and STAT4-dependent changes in chromatin remodeling of the CD25 gene. Gene activation requires binding of STAT4 to the PRRIII upstream regulatory element, the recruitment of the CREB-binding protein ( CBP), and chromatin remodeling including increased acetylation and decreased methylation of histones within the CD25 promoter. Evidence suggests that STAT4 also facilitates binding of other factors to the CD25 promoter including c-Jun. Thus, these results provide a model for STAT4-dependent gene induction and a mechanism for cytokine- induced expression of the CD25 gene.[1]


  1. STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. O'Sullivan, A., Chang, H.C., Yu, Q., Kaplan, M.H. J. Biol. Chem. (2004) [Pubmed]
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