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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

3-hydroxypropionaldehyde: applications and perspectives of biotechnological production.

3-hydroxypropionaldehyde (3-HPA) forms, together with HPA-hydrate and HPA-dimer, a dynamic, multi-component system ( HPA system) used in food preservation, as a precursor for many modern chemicals such as acrolein, acrylic acid, and 1,3-propanediol (1,3-PDO), and for polymer production. 3-HPA can be obtained both through traditional chemistry and bacterial fermentation. To date, 3-HPA has been produced from petrochemical resources as an intermediate in 1,3-PDO production. In vivo, glycerol is converted in one enzymatic step into 3-HPA. The 3-HPA-producing Lactobacillus reuteri is used as a probiotic in the health care of humans and animals. The biotechnological production of 3-HPA from renewable resources is desirable both for use of 3-HPA in foods and for the production of bulk chemicals. The main challenge will be the efficient production and recovery of pure 3-HPA.[1]


  1. 3-hydroxypropionaldehyde: applications and perspectives of biotechnological production. Vollenweider, S., Lacroix, C. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
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