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Joensuu, T. et al.

Inducibility of the avidin gene by progesterone is suppressed during estrogen-induced cytodifferentiation.

We have studied epithelial differentiation of the chick oviduct as induced by diethylstilbestrol (DES) and 17 beta-estradiol (E2). The proportion of goblet cells in the oviduct was slightly higher after E2 than after DES treatment. Also avidin induction by progesterone was stronger following DES than E2 priming. In the estrogen pretreated oviduct epithelium, avidin expression was induced by progesterone in the surface epithelial cells, protodifferentiated gland cells and tubular gland cells, but not in goblet cells. During prolonged estrogen treatment, however, the inducibility of avidin by progesterone ceased in tubular gland cells but not in surface epithelial cells. The estrogen action on the expression of avidin could be explained by estrogen-induced terminal differentiation of the epithelial gland cells or by a direct effect of estrogen on the progesterone action, for instance interaction of estrogen receptor and progesterone receptor in the regulation of transcription.[1]

References

Inducibility of the avidin gene by progesterone is suppressed during estrogen-induced cytodifferentiation. Joensuu, T., Niemelä, A., Kunnas, T., Salomaa, S., Alho, H., Vilja, P., Ylikomi, T., Kulomaa, M., Tuohimaa, P. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]

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