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Gene Review

PGR  -  progesterone receptor

Gallus gallus

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Disease relevance of PGR


High impact information on PGR


Biological context of PGR


Anatomical context of PGR


Associations of PGR with chemical compounds

  • In this study, one of the hormone-induced phosphorylation sites of chicken progesterone receptor, Ser530, was mutated to alanine, a nonphosphorylatable amino acid, and the transcriptional activity of the mutant receptor was compared with that of wild type in a transient cotransfection assay [5].
  • Estrogen and progesterone administration had effects also on ER and PR immunoreactivity [6].
  • Progesterone and estradiol participate in the regulation of several reproductive functions through interaction with intracellular progesterone receptors (PR) and estrogen receptors (ER), respectively [7].
  • Analysis of the amino acid sequence of the progesterone receptor deduced from the cDNA clones revealed a cysteine-rich region that was homologous to a region found in the estrogen and glucocorticoid receptors and to the avian erythroblastosis virus gag-erb-A fusion protein [8].
  • Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent [10].

Physical interactions of PGR

  • Addition to lysate of monoclonal antibody against hsp70 inhibits hsp90 binding to PR and destabilizes preformed complexes [12].
  • The purified DNA binding component (receptor A) of the chick oviduct progesterone receptor has been analyzed for its ability to bind to the cloned ovalbumin gene and to plasmid DNA of various structural compositions [13].
  • Interaction of eukaryotic class-B transcription factors and chick progesterone-receptor complex with conalbumin promoter sequences [14].

Enzymatic interactions of PGR


Regulatory relationships of PGR


Other interactions of PGR

  • Whereas numerous attempts to reversibly bind components to the activated receptor have been unsuccessful, we now report conditions that promote the reassociation of hsp90 and hsp70 to progesterone receptor [18].
  • Quantitative RT-PCR showed that gonadal ERalpha transcript levels in juvenile alligators decreased after E2 treatment whereas ERbeta and PR transcripts were not changed [19].
  • The level of PR mRNA was increased only by estrogen, while no steroid hormone affected the levels of ER and GR mRNAs [20].
  • No phosphorylation of progesterone receptor subunits was observed in the absence of EGF receptor, even when Ca2+ was substituted for Mg2+ and Mn2+ [15].
  • Various procedures were used to solubilize nuclear progesterone receptor (0.5 M KCl, micrococcal nuclease, NaDodSO4), and in no case was 32P-labeled B subunit detected in the extracts [21].

Analytical, diagnostic and therapeutic context of PGR


  1. Expression of active hormone and DNA-binding domains of the chicken progesterone receptor in E. coli. Eul, J., Meyer, M.E., Tora, L., Bocquel, M.T., Quirin-Stricker, C., Chambon, P., Gronemeyer, H. EMBO J. (1989) [Pubmed]
  2. Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons. Chandran, U.R., DeFranco, D.B. Mol. Endocrinol. (1992) [Pubmed]
  3. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Tsai, S.Y., Carlstedt-Duke, J., Weigel, N.L., Dahlman, K., Gustafsson, J.A., Tsai, M.J., O'Malley, B.W. Cell (1988) [Pubmed]
  4. Chicken oviduct progesterone receptor: location of specific regions of high-affinity binding in cloned DNA fragments of hormone-responsive genes. Mulvihill, E.R., LePennec, J.P., Chambon, P. Cell (1982) [Pubmed]
  5. Phosphorylation of Ser530 facilitates hormone-dependent transcriptional activation of the chicken progesterone receptor. Bai, W., Tullos, S., Weigel, N.L. Mol. Endocrinol. (1994) [Pubmed]
  6. Distribution of estrogen and progesterone receptors and steroid-regulated gene products in the chick oviduct. Isola, J.J. Mol. Cell. Endocrinol. (1990) [Pubmed]
  7. Changes in the content of progesterone receptor isoforms and estrogen receptor alpha in the chick brain during embryonic development. Camacho-Arroyo, I., González-Arenas, A., González-Agüero, G., Guerra-Araiza, C., González-Morán, G. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
  8. Molecular cloning of the chicken progesterone receptor. Conneely, O.M., Sullivan, W.P., Toft, D.O., Birnbaumer, M., Cook, R.G., Maxwell, B.L., Zarucki-Schulz, T., Greene, G.L., Schrader, W.T., O'Malley, B.W. Science (1986) [Pubmed]
  9. The general validity of the subunit model of the progesterone receptor from chick oviduct appears questionable. Comparison of progesterone and estrogen receptor. Gschwendt, M. Mol. Cell. Endocrinol. (1980) [Pubmed]
  10. Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent. Smith, D.F., Whitesell, L., Nair, S.C., Chen, S., Prapapanich, V., Rimerman, R.A. Mol. Cell. Biol. (1995) [Pubmed]
  11. Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins. Schowalter, D.B., Sullivan, W.P., Maihle, N.J., Dobson, A.D., Conneely, O.M., O'Malley, B.W., Toft, D.O. J. Biol. Chem. (1991) [Pubmed]
  12. Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events. Smith, D.F., Stensgard, B.A., Welch, W.J., Toft, D.O. J. Biol. Chem. (1992) [Pubmed]
  13. Interaction of the chick oviduct progesterone receptor with deoxyribonucleic acid. Hughes, M.R., Compton, J.G., Schrader, W.T., O'Malley, B.W. Biochemistry (1981) [Pubmed]
  14. Interaction of eukaryotic class-B transcription factors and chick progesterone-receptor complex with conalbumin promoter sequences. Davison, B.L., Mulvihill, E.R., Egly, J.M., Chambon, P. Cold Spring Harb. Symp. Quant. Biol. (1983) [Pubmed]
  15. Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor. Ghosh-Dastidar, P., Coty, W.A., Griest, R.E., Woo, D.D., Fox, C.F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes. Davidson, B.P., Dogra, S.C., May, B.K. Mol. Pharmacol. (2001) [Pubmed]
  17. Estrogen regulation of the biological activity of the avian oviduct progesterone receptor and its ability to induce avidin. Hora, J., Gosse, B., Rasmussen, K., Spelsberg, T.C. Endocrinology (1986) [Pubmed]
  18. Reconstitution of progesterone receptor with heat shock proteins. Smith, D.F., Schowalter, D.B., Kost, S.L., Toft, D.O. Mol. Endocrinol. (1990) [Pubmed]
  19. Molecular cloning of the estrogen and progesterone receptors of the American alligator. Katsu, Y., Bermudez, D.S., Braun, E.L., Helbing, C., Miyagawa, S., Gunderson, M.P., Kohno, S., Bryan, T.A., Guillette, L.J., Iguchi, T. Gen. Comp. Endocrinol. (2004) [Pubmed]
  20. Steroid hormone-induced expression of the chicken ovalbumin gene and the levels of nuclear steroid hormone receptors in chick oviduct. Arao, Y., Yamamoto, E., Ninomiya, Y., Masushige, S., Hasegawa, T., Kato, S. Biosci. Biotechnol. Biochem. (1996) [Pubmed]
  21. Tightly bound nuclear progesterone receptor is not phosphorylated in primary chick oviduct cultures. Garcia, T., Jung-Testas, I., Baulieu, E.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  22. Chemical and antigenic properties of pure 108,000 molecular weight chick progesterone receptor. Birnbaumer, M., Hinrichs-Rosello, M.V., Cook, R.G., Schrader, W.T., O'Malley, B.W. Mol. Endocrinol. (1987) [Pubmed]
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