Disease relevance of Oviducts

• The ability of the E. coli secretory apparatus to recognize chicken ovalbumin, which is normally synthesized and secreted in hen oviducts, suggests that common features exist in the secretion-recognition mechanisms found in these two organisms [1].
• These findings correlate with the observation that fertilin beta "knockout" sperm traverse the uterus but do not progress into the oviduct, contributing to the infertility of fertilin beta(-/-) male mice [2].
• However, E-cadherin is present in metaplastic OSE cells that resemble the more complex epithelia of the oviduct, endometrium and endocervix, and in primary epithelial ovarian carcinomas [3].
• Monospecific antibodies directed against the chicken progesterone receptor (PR) form B were used to screen a randomly primed phage lambda gt11 cDNA expression library prepared from size-fractionated chicken oviduct mRNA [4].
• Diverticulosis and salpingitis isthmica nodosa (SIN) of the fallopian tube. Estrogen-induced diverticulosis and SIN of the mouse oviduct [5].

Psychiatry related information on Oviducts

• Food deprivation provoked the involution of the oviduct and ovarian regression, as well as a decrease in the plasma concentrations of luteinising hormone (LH) and sex steroids (progesterone, testosterone and oestradiol) [6].

High impact information on Oviducts

• Regulated expression was tested after microinjection of the lysozyme deletion mutants into primary cultures of chicken oviduct cells using fluorescent antibodies against T antigen [7].
• Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells [8].
• Chicken oviduct progesterone receptor: location of specific regions of high-affinity binding in cloned DNA fragments of hormone-responsive genes [9].
• The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells [10].
• We transferred a chicken lysozyme gene recombinant by microinjection into primary cultures of chicken oviduct cells [8].

Chemical compound and disease context of Oviducts

• Using this direct assay for specific gene transcription, we explored the basis of previous reports indicating that steroid hormones also cause changes in oviduct chromatin structure that can be detected by Escherichia coli RNA polymerase [11].
• The oviduct lipid is extremely sensitive to mild acid hydrolysis and, based on a comparison with alpha-GlcNAc-phosphoryl-undecaprenol from Bacillus cereus, the oviduct lipid contains GlcNAc linked to a polyisoprene as the beta anomer, the polyisoprene containing an alpha-unsaturated isoprene unit [12].
• Host species-specific damage to oviduct mucosa by Neisseria gonorrhoeae lipopolysaccharide [13].
• Effects of physiological levels of estradiol-17 beta and progesterone on oviduct edema and ovum transport in the rabbit [14].
• The hypothesis that sialic acid has a role in spermatozoal sequestration within the hen's oviduct was tested by treating spermatozoa with Clostridium perfringens neuraminidase [15].

Biological context of Oviducts

• In addition, electrophoresis of oviduct nuclear RNA on agarose gels containing methylmercury hydroxide reveals multiple species of RNA that are from 1.3 to over 4 times larger than ovalbumin mRNA and hybridize to both structural and intervening sequences of the ovalbumin gene [16].
• We have monitored the secretion of chick oviduct proteins from Xenopus laevis oocytes microinjected with polyadenylated mRNA and found that chick ovalbumin and lysozyme are not secreted during the second meiotic metaphase, in contrast to the earlier prophase stage [17].
• Effect of estrogen on gene expression in chicken oviduct: evidence for transcriptional control of ovalbumin gene [18].
• A cDNA for the chicken progesterone receptor B subunit antigen (Mr, 108,000) has been isolated from a cDNA library prepared from size-selected chicken oviduct poly(A)+RNA [19].
• Evidence for specific DNA sequences in the nuclear acceptor sites of the avian oviduct progesterone receptor [20].

Anatomical context of Oviducts

• Colocalization of CB1 and beta2-adrenergic receptors in the oviduct muscularis implies that a basal endocannabinoid tone in collaboration with adrenergic receptors coordinates oviductal motility for normal journey of embryos into the uterus [21].
• The unexpected gene organisation is present both in oviduct cells highly specialised in ovalbumin synthesis and in erythrocytes [22].
• Ovalbumin messenger RNA (mRNAov) purified from hen oviduct was injected into Xenopus laevis oocytes [23].
• The chicken lysozyme gene is constitutively expressed in macrophages and controlled by steroid hormones in the oviduct [24].
• We examined the chromatin organizations of approximately 3 kb of DNA in the 5'-end flanking region of the ovalbumin gene in chicken erythrocyte and oviduct cell nuclei [25].

Associations of Oviducts with chemical compounds

• Quantitation of elongating form A and B RNA polymerases in chick oviduct nuclei and effects of estradiol [26].
• The receptor is present at very low levels compared to other steroid target tissues (50--100 fold less than chick oviduct) [27].
• Second, hybridization of end-labeled probes to oviduct nuclear RNA followed by digestion with S1 nuclease and analysis on polyacrylamide gels mapped more precisely the 5' and 3' ends of the precursor molecules, and these termini were coincident with the beginning and end of the structural sequence of the natural gene [28].
• The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes [29].
• The evidence presented here suggests that the stimulus-response coupling of the stimulating effect of prostaglandin E2 (PGE2) on ciliary activity of the rabbit oviduct is carried out by release of intracellular Ca2+ [30].

Gene context of Oviducts

• Wnt7a-deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are Müllerian duct derivatives [31].
• Here we show that in contrast to the HGF receptor, which was expressed at the basolateral surface, RON was localized at the apical surface of ciliated epithelia in the airways and oviduct [32].
• The mass of the SEC11 protein is very close to that found for two of the subunits of the canine and hen oviduct signal peptidases [33].
• In vivo experiments with sperm of Smcp(-/-) 129/Sv mice revealed that the migration of spermatozoa from the uterus into the oviduct is reduced [34].
• Few eggs are detected in the oviduct after stimulation with gonadotropins, and no two-cell embryos are recovered after mating Zp2-null females with normal male mice [35].

Analytical, diagnostic and therapeutic context of Oviducts

• When 3-d-withdrawn oviducts were restimulated with either estrogen or progesterone, in situ hybridization revealed that greater than or equal to 98% of the tubular gland cells contained ovalbumin mRNA [36].
• The expression of progesterone receptor (PR) and its induction by oestradiol during the embryogenesis of the chick bursa of Fabricius (BF) were studied by immunohistochemistry using three different polyclonal antibodies to the chicken oviduct PR [37].
• Since acute withdrawal from estrogen-stimulation markedly decreased the level of cPR mRNAs in chick oviduct when analyzed by Northern blotting, we conclude that estrogen-dependent stimulation of PR levels in the oviduct is a post-transcriptional process [38].
• The progestin-binding molecule resembled the progesterone receptor of the chick oviduct in molecular size (studied with HPLC) and binding properties [39].
• Progesterone binding components of chick oviduct. X. Purification by affinity chromatography [40].

References