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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.

Variation in the calpain-10 gene (CAPN10) has been associated with risk of type 2 diabetes in the Mexican American population of Starr County, Texas. We typed five polymorphisms in the calpain-10 gene (SNP-43, -43, -63, and -110 and Indel-19) to test for association with type 2 diabetes in 248 individuals representative of the mestizo population of Mexico City and Orizaba, Mexico including 134 patients with type 2 diabetes and 114 subjects with normal fasting blood glucose levels. We found a significant difference in SNP-44 allele and genotype frequencies between type 2 diabetic and non-diabetic subjects. The rare allele at SNP-44 was associated with increased risk of type 2 diabetes (odds ratio (OR)=2.72, 95% confidence interval (CI)=1.16-6.35, P=0.017). SNP-110, which is in perfect linkage disequilibrium with SNP-44, was also associated with type 2 diabetes. The SNP-43, Indel-19, and SNP-63 haplogenotype 112/121 associated with significantly increased risk (OR=2.16, 95% CI=1.31-3.57) of type 2 diabetes in Mexican Americans was not associated with significantly increased in risk in Mexicans (OR=1.15, 95% CI=0.57-2.34). The results suggest that variation in CAPN10 affects risk of type 2 diabetes in the mestizo population of central Mexico (Mexico City and Orizaba) and in Mexican Americans (Starr County, Texas).[1]

References

  1. Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population. del Bosque-Plata, L., Aguilar-Salinas, C.A., Tusié-Luna, M.T., Ramírez-Jiménez, S., Rodríguez-Torres, M., Aurón-Gómez, M., Ramírez, E., Velasco-Pérez, M.L., Ramírez-Silva, A., Gómez-Pérez, F., Hanis, C.L., Tsuchiya, T., Yoshiuchi, I., Cox, N.J., Bell, G.I. Mol. Genet. Metab. (2004) [Pubmed]
 
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