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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The meaning of H2O2 generation in carotid body cells for PO2 chemoreception.

The rat carotid body is able to generate H2O2 in type-I cells with the aid of an electron-transferring chain with cytochrome b as the major component as it can be detected by spectrophotometry as well as confocal laser-microscopy. This cytochrome b is reducible by hypoxia, but not by cyanide, indicating that it does not participate in the energy production by the respiratory chain. The carotid body possesses a glutathione peroxidase ( GPO) which scavenges H2O2 and other organic hydroperoxides. The nervous chemoreceptor discharge can be inhibited by external application of hydroperoxides with a similar half maximal value (60-80 microM) as used to stimulate GPO. A hypothetical signal chain is described which suggests the involvement of cytochrome b as an O2 sensor in PO2 chemoreception of the carotid body and the degradation of H2O2 by glutathione to control the K(+)-conductivity of carotid body cells.[1]


  1. The meaning of H2O2 generation in carotid body cells for PO2 chemoreception. Acker, H., Bölling, B., Delpiano, M.A., Dufau, E., Görlach, A., Holtermann, G. J. Auton. Nerv. Syst. (1992) [Pubmed]
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