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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Are thrombocyte membranes altered in Alzheimer's disease? A morphometric and biochemical study.

Morphometric analysis of thrombocytes from patients with Alzheimer's disease, from patients with multi-infarct dementia, and from young and age-matched healthy control donors, did not reveal any Alzheimer-related increase in internal membranes. Biochemical analysis showed a reduced cholesterol content of thrombocyte membrane preparations from Alzheimer patients relative to age-matched controls, but not relative to multi-infarct dementia patients. Overall distribution of protein kinase C activity (PKC) between cytosol and membrane, in resting as well as in activated thrombocytes from Alzheimer patients, was similar to that in the control groups. However, both Alzheimer and multi-infarct dementia patients had lower cytosolic levels of basal kinase and PKC activities than age-matched controls, while only Alzheimer patients had lower cytoskeletal PKC activity than controls.[1]

References

  1. Are thrombocyte membranes altered in Alzheimer's disease? A morphometric and biochemical study. Bosman, G.J., Schuurmans Stekhoven, J.H., Melenhorst, J.J., Van Zuylen, A.J., Bartholomeus, I.G., Van Kalmthout, P.J., De Grip, W.J. Neurobiol. Aging (1992) [Pubmed]
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