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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice.

BACKGROUND: In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in gastrulating embryos, is unknown, but a recent study has claimed that it plays a central role in germ cell specification. RESULTS: To test Dppa3's role in germ cell development, we disrupted the gene in mouse embryonic stem cells and generated mutant animals. We were able to obtain viable and fertile Dppa3-deficient animals of both sexes. Examination of embryonic and adult germ cells and gonads in Dppa3-deficient animals did not reveal any defects. However, most embryos derived from Dppa3-deficient oocytes failed to develop normally beyond the four-cell stage. CONCLUSION: We found that Dppa3 is an important maternal factor in the cleavage stages of mouse embryogenesis. However, it is not required for germ cell specification.[1]


  1. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. Bortvin, A., Goodheart, M., Liao, M., Page, D.C. BMC Dev. Biol. (2004) [Pubmed]
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