The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dppa3  -  developmental pluripotency-associated 3

Mus musculus

Synonyms: 2410075G02Rik, Cap1p, Compaction-associated protein 1, Crg1, Developmental pluripotency-associated protein 3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dppa3


High impact information on Dppa3

  • The stella positive nascent germ cells exhibit repression of homeobox genes, which may explain their escape from a somatic cell fate and the retention of pluripotency [2].
  • The parental genes for Nanog, Stella, and another embryonic gene, GDF3 are all located on chromosome 12p13 of the human genome, and on chromosome 6 in mouse [3].
  • Prdm1(also known as Blimp1)-positive lineage-restricted precursors of primordial germ cells (PGCs) initiate the formation of a cluster that differentiates into Dppa3 (also known as stella)-positive PGCs from around E7.0 onwards in the extra-embryonic mesoderm [4].
  • Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes [5].
  • Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells [5].

Biological context of Dppa3

  • CONCLUSION: We found that Dppa3 is an important maternal factor in the cleavage stages of mouse embryogenesis [6].
  • Using single-cell gene expression profiles, we also show that only those cells with the highest expression of fragilis subsequently express stella, a gene that we detected exclusively in lineage-restricted germ cells [2].
  • Other physiological studies pointed out the involvement of CB1 receptors in the modulation of hippocampal glutamatergic synaptic transmission and long-term potentiation (Stella et al., 1997; Misner and Sullivan, 1999), but anatomical studies could not confirm the existence of CB1 receptors on glutamatergic terminals [7].
  • H. stella populations exhibit ancient haplotype segregation that may represent currently unrecognized allopatric species [8].

Anatomical context of Dppa3

  • Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours [9].
  • However, most embryos derived from Dppa3-deficient oocytes failed to develop normally beyond the four-cell stage [6].
  • Examination of embryonic and adult germ cells and gonads in Dppa3-deficient animals did not reveal any defects [6].

Other interactions of Dppa3

  • To address these issues, whole embryos and cryosections of embryos were immunostained with anti-NANOG and anti-STELLA/PGC7 antibodies [10].


  1. Differentiation of embryonic stem cells after transplantation into peritoneal cavity of irradiated mice and expression of specific germ cell genes in pluripotent cells. Gordeeva, O., Zinovieva, R., Smirnova, Y., Payushina, O., Nikonova, T., Khrushchov, N. Transplant. Proc. (2005) [Pubmed]
  2. A molecular programme for the specification of germ cell fate in mice. Saitou, M., Barton, S.C., Surani, M.A. Nature (2002) [Pubmed]
  3. Multiple retropseudogenes from pluripotent cell-specific gene expression indicates a potential signature for novel gene identification. Pain, D., Chirn, G.W., Strassel, C., Kemp, D.M. J. Biol. Chem. (2005) [Pubmed]
  4. Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling. Yabuta, Y., Kurimoto, K., Ohinata, Y., Seki, Y., Saitou, M. Biol. Reprod. (2006) [Pubmed]
  5. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Sato, M., Kimura, T., Kurokawa, K., Fujita, Y., Abe, K., Masuhara, M., Yasunaga, T., Ryo, A., Yamamoto, M., Nakano, T. Mech. Dev. (2002) [Pubmed]
  6. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. Bortvin, A., Goodheart, M., Liao, M., Page, D.C. BMC Dev. Biol. (2004) [Pubmed]
  7. Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Hájos, N., Ledent, C., Freund, T.F. Neuroscience (2001) [Pubmed]
  8. Mitochondrial phylogeny of African wood mice, genus Hylomyscus (Rodentia, Muridae): implications for their taxonomy and biogeography. Nicolas, V., Quérouil, S., Verheyen, E., Verheyen, W., Mboumba, J.F., Dillen, M., Colyn, M. Mol. Phylogenet. Evol. (2006) [Pubmed]
  9. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Bowles, J., Teasdale, R.P., James, K., Koopman, P. Cytogenet. Genome Res. (2003) [Pubmed]
  10. Nanog expression in mouse germ cell development. Yamaguchi, S., Kimura, H., Tada, M., Nakatsuji, N., Tada, T. Gene Expr. Patterns (2005) [Pubmed]
WikiGenes - Universities