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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Polysomnography in transgenic hSOD1 mice as Down syndrome model.

Sleep-wake homeostasis is crucial for behavioral performances and memory in the general population and in learning disability populations among them Down syndrome patients. We investigated, in a mouse model of Down syndrome, cortical EEG and sleep-wake architecture under baseline conditions and after a 4 hr sleep deprivation (SD). Young heterozygous transgenic mice (S/+) for the human Cu/Zn superoxide dismutase (hSOD-1) were obtained on FVB/N background. Baseline records for slow wave sleep (SWS) and wake (W) parameters were the same in S/+ and control mice whereas paradoxical sleep (PS) episode number decreased and PS latency increased after light off in S/+ mice. These data correlate well the polysomnographic phenotype of young DS patients.[1]


  1. Polysomnography in transgenic hSOD1 mice as Down syndrome model. Colas, D., London, J., Cespuglio, R., Sarda, N. J. Neural Transm. Suppl. (2003) [Pubmed]
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