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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sleep Deprivation

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Disease relevance of Sleep Deprivation


Psychiatry related information on Sleep Deprivation


High impact information on Sleep Deprivation

  • Consistent with the protective effect of heat-shock genes, was the observation that flies carrying a mutation for the heat-shock protein Hsp83 (Hsp83(08445)) showed exaggerated homeostatic response and died after sleep deprivation [11].
  • During sleep deprivation, glucose levels and insulin secretion rose again to reach a maximum at a time corresponding to the beginning of the habitual sleep period [12].
  • After sleep deprivation, the blunting of the normal sleep-related growth-hormone (GH) pulse is compensated during the day [13].
  • We measured serum thyrotropin every 15 minutes during the night of sleep deprivation, thyrotropin bioactivity, the thyrotropin response to protirelin the next afternoon, and other indexes of hypothalamic-pituitary-thyroid function [14].
  • Effects of tryptophan depletion in drug-free depressed patients who responded to total sleep deprivation [15].

Chemical compound and disease context of Sleep Deprivation


Biological context of Sleep Deprivation


Anatomical context of Sleep Deprivation


Gene context of Sleep Deprivation

  • This study compares cortical EEG and architecture of the sleep-waking cycle in adult Ube3a m-/p+ mice compared with those of age-matched WT (m+/p+) mice, under baseline conditions or after 4-h sleep deprivation (SD) [30].
  • Therefore, we studied the effect of sleep deprivation on nocturnal ghrelin secretion [31].
  • Sleep deprivation delayed the normal night time increase in gastric TFF2 and resulted in an overall reduction in TFF2 secretion [32].
  • Inhibition of either IL-1 or TNF inhibits spontaneous sleep and the sleep rebound that occurs after sleep deprivation [33].
  • The studies include profiles of GH secretion in normal men and women in fed and fasted states; analysis of GH secretion during sleep; and administration of GHRH during different stages of sleep and after sleep deprivation [34].

Analytical, diagnostic and therapeutic context of Sleep Deprivation

  • We investigated its role in sleep and sleep regulation by comparing baseline recordings and the effects of sleep deprivation in PrP knockout mice (129/SV) and wild-type controls (129/SV x C57BL/6), which are the mice used for most gene targeting experiments and whose behavior is not well characterized [35].
  • METHOD: Regional cerebral glucose metabolism was assessed by positron emission tomography (PET) with [18F]deoxyglucose (FDG) before and after total sleep deprivation in 15 unmedicated awake patients with unipolar major depression and 15 normal control subjects, who did the continuous performance test during FDG uptake [36].
  • The changes in non-REM sleep EEG spectra are dissimilar from the spectral changes induced by sleep deprivation and exhibit a close temporal association with the melatonin rhythm and the endogenous circadian phase of sleep consolidation [37].
  • The interventions studied included antidepressant medication, estrogen therapy, critically timed sleep deprivation, and bright light therapy [38].
  • Response to total sleep deprivation before and during treatment with fluvoxamine or maprotiline in patients with major depression--results of a double-blind study [39].


  1. Sleep electroencephalogram delta-frequency amplitude, night plasma levels of tumor necrosis factor alpha, and human immunodeficiency virus infection. Darko, D.F., Miller, J.C., Gallen, C., White, J., Koziol, J., Brown, S.J., Hayduk, R., Atkinson, J.H., Assmus, J., Munnell, D.T., Naitoh, P., McCutchan, J.A., Mitler, M.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Development of the control of breathing: implications for sleep-related breathing disorders in infants. Gaultier, C. Sleep. (2000) [Pubmed]
  3. Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation. Iranzo, A., Valldeoriola, F., Santamaría, J., Tolosa, E., Rumià, J. J. Neurol. Neurosurg. Psychiatr. (2002) [Pubmed]
  4. Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in obstructive sleep apnea syndrome. Peled, N., Greenberg, A., Pillar, G., Zinder, O., Levi, N., Lavie, P. Am. J. Hypertens. (1998) [Pubmed]
  5. Melatonin and its new agonist S-20098 restore synchronized sleep fragmented by experimental trypanosome infection in the rat. Grassi-Zucconi, G., Semprevivo, M., Mocaer, E., Kristensson, K., Bentivoglio, M. Brain Res. Bull. (1996) [Pubmed]
  6. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. Redwine, L., Hauger, R.L., Gillin, J.C., Irwin, M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  7. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Zavodny, J., Roth, C., Bassetti, C.L., Mathis, J., Douglas, N.J., Gugger, M. Sleep. (2006) [Pubmed]
  8. The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography. Wu, J.C., Gillin, J.C., Buchsbaum, M.S., Hershey, T., Hazlett, E., Sicotte, N., Bunney, W.E. Sleep. (1991) [Pubmed]
  9. Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. Blier, P., de Montigny, C., Chaput, Y. Journal of clinical psychopharmacology. (1987) [Pubmed]
  10. Cocaine effects in sleep-deprived humans. Fischman, M.W., Schuster, C.R. Psychopharmacology (Berl.) (1980) [Pubmed]
  11. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Shaw, P.J., Tononi, G., Greenspan, R.J., Robinson, D.F. Nature (2002) [Pubmed]
  12. Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. Van Cauter, E., Blackman, J.D., Roland, D., Spire, J.P., Refetoff, S., Polonsky, K.S. J. Clin. Invest. (1991) [Pubmed]
  13. Effect of sleep deprivation on overall 24 h growth-hormone secretion. Brandenberger, G., Gronfier, C., Chapotot, F., Simon, C., Piquard, F. Lancet (2000) [Pubmed]
  14. Serum thyrotropin concentrations and bioactivity during sleep deprivation in depression. Orth, D.N., Shelton, R.C., Nicholson, W.E., Beck-Peccoz, P., Tomarken, A.J., Persani, L., Loosen, P.T. Arch. Gen. Psychiatry (2001) [Pubmed]
  15. Effects of tryptophan depletion in drug-free depressed patients who responded to total sleep deprivation. Neumeister, A., Praschak-Rieder, N., Hesselmann, B., Vitouch, O., Rauh, M., Barocka, A., Tauscher, J., Kasper, S. Arch. Gen. Psychiatry (1998) [Pubmed]
  16. Can lithium carbonate prolong the antidepressant effect of sleep deprivation? Baxter, L.R. Arch. Gen. Psychiatry (1985) [Pubmed]
  17. Effects of sleep deprivation on mood and central amine metabolism in depressed patients. Post, R.M., Kotin, J., Goodwin, F.K. Arch. Gen. Psychiatry (1976) [Pubmed]
  18. A specific role for the thalamus in mediating the interaction of attention and arousal in humans. Portas, C.M., Rees, G., Howseman, A.M., Josephs, O., Turner, R., Frith, C.D. J. Neurosci. (1998) [Pubmed]
  19. Impact of sleep deprivation and subsequent recovery sleep on cortisol in unmedicated depressed patients. Voderholzer, U., Hohagen, F., Klein, T., Jungnickel, J., Kirschbaum, C., Berger, M., Riemann, D. The American journal of psychiatry. (2004) [Pubmed]
  20. Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. Benedetti, F., Serretti, A., Colombo, C., Campori, E., Barbini, B., di Bella, D., Smeraldi, E. The American journal of psychiatry. (1999) [Pubmed]
  21. Adenosine and sleep-wake regulation. Basheer, R., Strecker, R.E., Thakkar, M.M., McCarley, R.W. Prog. Neurobiol. (2004) [Pubmed]
  22. A prospective study of sleep duration and coronary heart disease in women. Ayas, N.T., White, D.P., Manson, J.E., Stampfer, M.J., Speizer, F.E., Malhotra, A., Hu, F.B. Arch. Intern. Med. (2003) [Pubmed]
  23. Diurnal rhythms of aminopyrine metabolism: failure to sleep deprivation to affect them. Poley, G.E., Shively, C.A., Vesell, E.S. Clin. Pharmacol. Ther. (1978) [Pubmed]
  24. Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Parry, B.L., Javeed, S., Laughlin, G.A., Hauger, R., Clopton, P. Biol. Psychiatry (2000) [Pubmed]
  25. Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Huitron-Resendiz, S., Sanchez-Alavez, M., Wills, D.N., Cravatt, B.F., Henriksen, S.J. Sleep. (2004) [Pubmed]
  26. Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. Irwin, M., McClintick, J., Costlow, C., Fortner, M., White, J., Gillin, J.C. FASEB J. (1996) [Pubmed]
  27. Serum prolactin, growth hormone, total corticoids, thyroid hormones and thyrotropine during serial therapeutic sleep deprivation. Kuhs, H., Farber, D., Tolle, R. Biol. Psychiatry (1996) [Pubmed]
  28. Aqueous humor flow during sleep. Reiss, G.R., Lee, D.A., Topper, J.E., Brubaker, R.F. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  29. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Bjorvatn, B., Grønli, J., Hamre, F., Sørensen, E., Fiske, E., Bjørkum, A.A., Portas, C.M., Ursin, R. Neuroscience (2002) [Pubmed]
  30. Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome. Colas, D., Wagstaff, J., Fort, P., Salvert, D., Sarda, N. Neurobiol. Dis. (2005) [Pubmed]
  31. Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Dzaja, A., Dalal, M.A., Himmerich, H., Uhr, M., Pollmächer, T., Schuld, A. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  32. The diurnal rhythm of the cytoprotective human trefoil protein TFF2 is reduced by factors associated with gastric mucosal damage: ageing, Helicobacter pylori infection, and sleep deprivation. Johns, C.E., Newton, J.L., Westley, B.R., May, F.E. Am. J. Gastroenterol. (2005) [Pubmed]
  33. The role of cytokines in physiological sleep regulation. Krueger, J.M., Obál, F.J., Fang, J., Kubota, T., Taishi, P. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  34. Physiological role of somatostatin on growth hormone regulation in humans. Thorner, M.O., Vance, M.L., Hartman, M.L., Holl, R.W., Evans, W.S., Veldhuis, J.D., Van Cauter, E., Copinschi, G., Bowers, C.Y. Metab. Clin. Exp. (1990) [Pubmed]
  35. Sleep and sleep regulation in normal and prion protein-deficient mice. Tobler, I., Deboer, T., Fischer, M. J. Neurosci. (1997) [Pubmed]
  36. Effect of sleep deprivation on brain metabolism of depressed patients. Wu, J.C., Gillin, J.C., Buchsbaum, M.S., Hershey, T., Johnson, J.C., Bunney, W.E. The American journal of psychiatry. (1992) [Pubmed]
  37. Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. Dijk, D.J., Shanahan, T.L., Duffy, J.F., Ronda, J.M., Czeisler, C.A. J. Physiol. (Lond.) (1997) [Pubmed]
  38. Treatment of postpartum depression, part 1: a critical review of biological interventions. Dennis, C.L., Stewart, D.E. The Journal of clinical psychiatry. (2004) [Pubmed]
  39. Response to total sleep deprivation before and during treatment with fluvoxamine or maprotiline in patients with major depression--results of a double-blind study. Kasper, S., Voll, G., Vieira, A., Kick, H. Pharmacopsychiatry (1990) [Pubmed]
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