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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence.

To identify proteins involved in tomato Cf-9 resistance protein function, a yeast two-hybrid screen was undertaken using the cytoplasmic C-terminus of Cf-9 as bait. A thioredoxin-homologous clone, interacting specifically with Cf-9, was identified and called CITRX (Cf-9-interacting thioredoxin). Virus-induced gene silencing (VIGS) of CITRX resulted in an accelerated Cf-9/Avr9-triggered hypersensitive response in both tomato and Nicotiana benthamiana, accompanied by enhanced accumulation of reactive oxygen species, alteration of protein kinase activity and induction of defence-related genes. VIGS of CITRX also conferred increased resistance to the fungal pathogen Cladosporium fulvum in the otherwise susceptible Cf0 tomato. CITRX acts as a negative regulator of the cell death and defence responses induced through Cf-9, but not Cf-2. Recognition of the Cf-9 C-terminus by CITRX is necessary and sufficient for this negative regulation. This is the first study that implicates thioredoxin activity in the regulation of plant disease resistance.[1]


  1. CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence. Rivas, S., Rougon-Cardoso, A., Smoker, M., Schauser, L., Yoshioka, H., Jones, J.D. EMBO J. (2004) [Pubmed]
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