- Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. Liang, Y., Li, C., Guzman, V.M., Chang, W.W., Evinger, A.J., Pablo, J.V., Woodward, D.F. Br. J. Pharmacol. (2004)