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Okuyama, S. et al.

Okuyama, Sawasaki, Yokogoshi,

Conductor compounds of phenylpentane in Mycoleptodonoides aitchisonii mycelium enhance the release of dopamine from rat brain striatum slices.

Monoterpene compound is a major component of essential oils in various aromatic species. Previous reports about the monoterpene compound linalool and its effect on the brain neurotransmitters glutamic acid, GABA and acetylcholine, but not catecholamines, have been reported. In this study, we investigated the effect of linalool or conductor compounds of phenylpentane, including 1-phenyl-3-pentanol and 1-phenyl-3-pentanone, on dopamine release using rat striatal slices. The edible mushroom Mycoleptodonoides aitchisonii belongs to the Climacodontaceae family, and its cultivate medium or mycelium contains derivatives of the fragrant conductor compound, phenylpentane. Compared to basal levels, 2.5 microg linalool increased dopamine from striatal slices 3-fold. A 4-fold increase in dopamine release resulted from 2.5 microg 1-phenyl-3-pentanol administration, while a half dose of this compound induced a 2.5-fold increase. A greater than 2-fold increase resulted with 2.5 microg 1-phenyl-3-pentanone. These data indicate that striatum has sensitivity for these fragrant compounds and different releasing effects result with differ structures. These actions may affect other neurotransmitters and influence brain function.[1]

References

Conductor compounds of phenylpentane in Mycoleptodonoides aitchisonii mycelium enhance the release of dopamine from rat brain striatum slices. Okuyama, S., Sawasaki, E., Yokogoshi, H. Nutritional neuroscience. (2004) [Pubmed]

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