Disease relevance of C11389

• We have purified and characterized the three proteins from a P-450-dependent linalool 8-methyl hydroxylase in Pseudomonas putida (incognita) strain PpG777 [1].
• Thus, scent of lavender oil and its active component, linalool, affect autonomic nerves, suppress lipolysis through a histaminergic response, and enhance appetite and body weight [2].
• Anosmia induced by pretreatment of the nasal cavity by application of ZnSO4 eliminated the effects of both SLVO and scent of linalool on RSNA, GVNA and BP [3].
• Thauera linaloolentis sp. nov. and Thauera terpenica sp. nov., isolated on oxygen-containing monoterpenes (linalool, menthol, and eucalyptol) nitrate [4].
• We conducted a series of bioassays to evaluate the toxicity of the ether extract, and mixtures of this extract with citral, 5,7-dimethoxycoumarin. and linalool incorporated to C. capitata larvae's natural diet (lemon slices endocarp) at a concentration of 250 microg/g of diet [5].

Psychiatry related information on C11389

• A blend of active cuticular compounds with linalool elicited both attraction and copulation behavior in patrolling males [6].

High impact information on C11389

• Green fluorescent protein localization experiments suggest that a change in subcellular localization led to the FaNES1 enzyme encountering both GPP and FPP, allowing it to produce linalool and nerolidol [7].
• The utility of these cyclization reactions was illustrated with the synthesis of a key tetrahydrofuran building block for the synthesis of linalool oxide and rotundisine [8].
• The partial pressure rises also in compounds with a low H, but more than 1,000-fold higher liquid phase concentrations of linalool and 1,8-cineole are necessary to increase intercellular partial pressure high enough to balance stomatal closure [9].
• The local lymph node assay (LLNA) was used to investigate the sensitizing potential of pure linalool, two samples of air-exposed linalool, and oxidation products of linalool (an alpha,beta-unsaturated aldehyde, a mixture of two hydroperoxides, and an alcohol) [10].
• Cytochrome P-450lin catalyzes the 8-methyl hydroxylation of linalool as the first committed step of its utilization by Pseudomonas incognita as the sole carbon source [11].

Chemical compound and disease context of C11389

• Male Wistar rats were given, by gastric intubation, 1.5 g citral or linalool/kg body weight/day for 5 days [12].
• In vapor phase toxicity tests, verbenone (11.48 mg/L air) was the most toxic compound followed by (-)-alpha-thujone (18.43 mg/L of air), thymol (18.76 mg/L of air), alpha-terpineol (21.89 mg/L of air), (+/-)-camphor (24.59 mg/L of air), linalool (26.20 mg/L of air), and marjoram oil (38.28 mg/L of air) on the basis of the 24-h LC50 values [13].
• The main causes of allergic contact dermatitis were 2 perfume oils (12 cases) and their ingredients geraniol (12 cases), benzaldehyde(9), cinnamic aldehyde (6), linalool, neroli oil, terpenes of lemon oil and orange oil (4 each) [14].
• Finally, female adults of C. capitata fed on diets containing additional amounts of ether extract, 5,7-dimethoxycoumarin, and linalool, were exposed to different photoperiods to test for phototoxicity [5].
• Facial psoriasis caused by contact allergy to linalool and hydroxycitronellal in an after-shave [15].

Biological context of C11389

• In the case of linalool, the lag times for PL with 5 and 10% levels of enhancer were 7.0- and 5.2-fold less compared with 1% level [16].
• (E)-Nerolidol, a minor component of the hydrodistillate, as well as linalool, were shown to have a more potent and selective effect on the trypanosomes [IC50 = 1.7 and 2.5 microg/mL (7.6 and 16.3 microM) with SI = 35.7 and > 40, respectively] [17].
• In addition, OTFP also reduced the amplitude of the EAG response to linalool, a monoterpenic alcohol, but not its kinetics [18].
• Thus, it was concluded that scent of lavender oil and its active component, linalool, affects autonomic neurotransmission and reduces blood pressure through the central histaminergic nervous system and the SCN [3].
• Biotransformation of (R)-(-)-linalool with the same strain yielded almost pure trans-furanoid and trans-pyranoid linalool oxide (ee > 95) [19].

Anatomical context of C11389

• Discrimination between Enantiomers of Linalool by Olfactory Receptor Neurons in the Cabbage Moth Mamestra brassicae (L.) [20].
• Finally, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) eliminated RSNA and BP suppression and the elevation of GVNA due to SLVO or linalool [3].
• The negative mucosa potential (NMP), a peripheral correlate of trigeminal activation, was recorded from the nasal mucosa in response to stimulation with varying concentrations of the mixed olfactory/trigeminal stimulants menthol and linalool [21].
• Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells [22].
• Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties [23].

Associations of C11389 with other chemical compounds

• The stoichiometric coefficients and apparent formation constants (Kf) of alpha-terpineol, thymol, geraniol and linalool complexes with beta-cyclodextrin (beta-CD) were determined using HPLC with a porous graphitic carbon (PGC) chromatographic support [24].
• The potential use of chiral enhancers, menthol and linalool, was also investigated [25].
• In the present study olfactory conditioning of the proboscis extension response was performed to determine the moths' ability to learn and discriminate three plant odorants: beta-ocimene and beta-myrcene (activating the same receptor neurone type), and racemic linalool (activating two different types) [26].
• The respective alcoholic terpenes carvacrol, linalool, and alpha-terpineol were used at 5% w/v in propylene glycol (PG) to increase the in vitro permeation of haloperidol (HP) through human skin [27].
• Pediculicidal activity of linalool was comparable with that of d-phenothrin and pyrethrum [28].

Gene context of C11389

• The emission of (E)-beta-ocimene and linalool was lower in Sirtaki and Fame leaves than in Bianca and Rondena [29].
• The aim of our study was to investigate the protective effects of intraperitoneally-administrated vitamin E, dlalpha lipoic acid, and linalool on the level of total lipid and fatty acid in guinea pig brains with oxidative stress that was induced by H2O2 [30].
• The data suggest that the anticonvulsant mode of action of linalool includes a direct interaction with the NMDA receptor complex [31].

Analytical, diagnostic and therapeutic context of C11389

• Molecular cloning and characterization of a new linalool synthase [32].
• Carvacrol, linalool and alpha-terpineol (5% w/v) in 50% ethanol were used to enhance the permeation of haloperidol (HP) through human skin in vitro and their enhancement mechanism was investigated with HP-stratum corneum (SC) binding studies, fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) [33].
• Metabolites isolated from urine of rats after oral administration of linalool (VII) were 8-hydroxy-linalool (VIII) and 8-carboxy-linalool (IX) [34].
• Neither the crude essential oil nor the purified linalool fraction is toxic to mammalian cells, which suggests that the essential oil or its purified components may be useful to control the microbial population in patients with fixed orthodontic appliances [35].
• As the proportion of infinity USFA and infinity PUFA were found to be highest in the linalool group, they were decreased in the H2O2 group when compared to the control group [30].

References