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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The plasma membrane Ca2+ pump from proximal kidney tubules is exclusively localized and active in caveolae.

Plasma membrane Ca2+-ATPase is involved in the fine-tuned regulation of intracellular Ca2+. In this study, the presence of Ca2+-ATPase in caveolae from kidney basolateral membranes was investigated. With the use of a discontinuous sucrose gradient, we show that Ca2+-ATPase is exclusively located and fully active in caveolin-containing microdomains. Treatment with methyl-beta-cyclodextrin--a cholesterol chelator--leads to a spreading of both caveolin and completely inactive Ca2+-ATPase toward high-density fractions. These data support the view that Ca2+ fluxes mediated by Ca2+-ATPase in kidney epithelial cells occur only in caveolae, being strictly dependent on the integrity of these microdomains.[1]

References

  1. The plasma membrane Ca2+ pump from proximal kidney tubules is exclusively localized and active in caveolae. Tortelote, G.G., Valverde, R.H., Lemos, T., Guilherme, A., Einicker-Lamas, M., Vieyra, A. FEBS Lett. (2004) [Pubmed]
 
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