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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types.

C2C12 myoblasts expressing the androgen receptor ( AR) were used to analyze the role of androgen- AR signaling pathway in skeletal muscle development. Marked up-regulation of AR expression was observed in differentiated myotubes. A nuclear run-on transcription assay demonstrated that transcription of the AR gene is increased during skeletal muscle cell differentiation. Regulation of skeletal muscle-specific protein expression by the androgen- AR signaling pathway was further analyzed using quadriceps skeletal muscle from wild-type (WT) and AR knock-out (ARKO) male mice. A histological analysis of quadriceps skeletal muscle indicates no morphological differences between ARKO and WT mice. However, the androgen- AR signaling pathway increases expression of slow-twitch-specific skeletal muscle proteins and downregulates fast-twitch-specific skeletal muscle proteins, resulting in an increase of slow-twitch muscle fiber type cells in quadriceps muscle.[1]

References

  1. Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types. Altuwaijri, S., Lee, D.K., Chuang, K.H., Ting, H.J., Yang, Z., Xu, Q., Tsai, M.Y., Yeh, S., Hanchett, L.A., Chang, H.C., Chang, C. Endocrine (2004) [Pubmed]
 
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