High impact information on Muscle Fibers, Slow-Twitch

• Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters [1].
• In muscle, we find differential levels of IDE and NEP in fast versus slow twitch muscle fibers that varies with aging [2].
• The use of myofibrillar adenosine triphosphatase showed that all fibers darkly stained uniformly at a pH of 9.6, 4.6 and 4.3, suggesting that they were myofibrillar intermediate muscle fibers [3].
• Slow-twitch muscle fibers, identified by NADH-tetrazolium reductase staining, possessed more GLUT-3 protein than fast-twitch fibers [4].
• Here we show that both CS isoforms coexist in slow-twitch muscle fibers as indicated by indirect immunofluorescent staining of cryosections with affinity-purified antibodies specific for each CS isoform [5].

Anatomical context of Muscle Fibers, Slow-Twitch

• However, the androgen-AR signaling pathway increases expression of slow-twitch-specific skeletal muscle proteins and downregulates fast-twitch-specific skeletal muscle proteins, resulting in an increase of slow-twitch muscle fiber type cells in quadriceps muscle [6].
• The proportion of slow-twitch muscle fibers, as indicated by the myofibrillar adenosine triphosphatase (ATPase) stain, increased in the diaphragm, but not in the intercostal muscles [7].

Associations of Muscle Fibers, Slow-Twitch with chemical compounds

• The rate of SR Ca(2+) uptake was increased in slow-twitch muscle fibers (14.2 +/- 1.0 vs. 19.6 +/- 2. 5 nmol. min(-1). mg fiber protein(-1), P < 0.05) and not altered in fast-twitch fibers [8].
• The accuracy of the method was assessed in rabbit muscles after the injection of two gadolinium chelates (Gd-DTPA and Gd-DOTA) with the aim of improving the in vivo characterization of fast-twitch and slow-twitch muscle fiber types [9].
• Interactions between the two myosin heads were studied in skinned rabbit slow-twitch muscle fibers activated in the presence of vanadate (Vi), a phosphate analog [10].
• The lactate change ratio (post-exercise/pre-exercise) correlated negatively to the percentage of slow-twitch muscle fibers (P less than 0.05) in the patients but not in the healthy controls [11].

Gene context of Muscle Fibers, Slow-Twitch

• Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast- and slow-twitch muscle fibers [12].
• Our results seem to be consistent with a maturational-related abnormality and/or with altered modulatory mechanisms of SR Ca(2+)-transport in DM slow-twitch muscle fibers [13].
• PURPOSE: Fast-twitch and slow-twitch muscle fibers are known to have distinct metabolic properties [14].
• Subjects with the highest percentage of slow-twitch muscle fibers (mean ST%=51.14) rated LE and CE significantly lower ( mean of all power outputs, 0-300 W) than those with the lowest ST% (mean=34.52) [15].
• Heterogeneous expression of myosin light chain 1 in a human slow-twitch muscle fiber [16].

Analytical, diagnostic and therapeutic context of Muscle Fibers, Slow-Twitch

• Heterogeneous expression of myosin light chain 1 was observed in a human slow-twitch muscle fiber on two dimensional gel electrophoresis [16].

References