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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha.

ATG genes are required for autophagy-related processes that transport proteins/organelles destined for proteolytic degradation to the vacuole. Here, we describe the identification and characterisation of the Hansenula polymorpha ATG21 gene. Its gene product Hp-Atg21p, fused to eGFP, had a dual location in the cytosol and in peri-vacuolar dots. We demonstrate that Hp-Atg21p is essential for two separate modes of peroxisome degradation, namely glucose-induced macropexophagy and nitrogen limitation-induced microautophagy. In atg21 cells subjected to macropexophagy conditions, sequestration of peroxisomes tagged for degradation is initiated but fails to complete.[1]

References

  1. Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha. Leão-Helder, A.N., Krikken, A.M., Gellissen, G., van der Klei, I.J., Veenhuis, M., Kiel, J.A. FEBS Lett. (2004) [Pubmed]
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